电感耦合等离子体-飞行时间质谱仪（ICP-TOF-MS）的物理设计与仿真研究

Background]: Inductively coupled plasma mass spectrometer (ICP-MS) is an important technique for elemental and isotope ratio analysis. Among them, time-of-flight mass spectrometer (TOF-MS) has been widely used in the field of organic molecule and biomedical detection due to its simple principle, high sensitivity, wide detection quality range, and ability to obtain a full range of mass information at one time. [Purpose]: This study aims to meet the quality analysis requirements of uranium and transuranic elements during the operation of Thorium-based Molten Salt Reactors (TMSR) by designing and simulating the physical integration of an inductively coupled plasma ion source with TOF-MS. [Methods]: A physical model was developed in accordance with the structural principles. Ion optical simulation software was employed to simulate the configurations of the ion transport system, including the differential cone, deflection lens, collision cell, direct current quadrupoles (DCQ), and single lens. The rationality of these designs was validated through simulation results. The optimal collision pressure for the collision cell was determined by systematically varying the pressure. Additionally, the TOF design parameters were calculated, and simulations were conducted to optimize the voltage settings, thereby enhancing the resolution. [Results]: With the assistance of simulation, the optimal guide cone voltage for the differential cone system was determined to be -30 V. The optimal deflection voltage combination for the designed deflection lens system was identified as -56 V and -530 V. The optimal collision pressure within the collision cell was established as 1.6 Pa. The DCQ coupled with the single-lens system can introduce ions into the TOF acceleration field with an initial kinetic energy of approximately 4 eV in a near-horizontal state. When the pulse field voltage is set to 200 V, the accelerating voltage is -1600 V, the first-stage reflection voltage is 48 V, and the second-stage reflection voltage is 680 V, the mass resolution (M/M) of the TOF-MS exceeds 4000. [Conclusions]: The research results provide an important theoretical reference for the subsequent processing, manufacturing, construction and commissioning.