Physics with high-luminosity proton-nucleus collisions at the LHC

The physics case for the operation of high-luminosity proton-nucleus ($pA$) collisions during Run 3 and 4 at the LHC is reviewed. The collection of $\mathcal{O}$(1-10 pb$^{-1}$) of proton-lead ($p$Pb) collisions at the LHC will provide unique physics opportunities in a broad range of topics including proton and nuclear parton distribution functions (PDFs and nPDFs), generalised parton distributions (GPDs), transverse momentum dependent PDFs (TMDs), low-$x$ QCD and parton saturation, hadron spectroscopy, baseline studies for quark-gluon plasma and parton collectivity, double and triple parton scatterings (DPS/TPS), photon-photon collisions, and physics beyond the Standard Model (BSM); which are not otherwise as clearly accessible by exploiting data from any other colliding system at the LHC. This report summarises the accelerator aspects of high-luminosity $pA$ operation at the LHC, as well as each of the physics topics outlined above, including the relevant experimental measurements that motivate -- much -- larger $pA$ datasets.