pH响应型CaCO3纳米粒递送抗生素治疗胞内MRSA感染
金黄色葡萄球菌，尤其是耐甲氧西林金黄色葡萄球菌，可通过侵入宿主细胞逃避免疫清除，导致反复感染。传统抗生素难以有效清除胞内菌，因此本研究构建了一种pH响应性纳米递送系统，以碳酸钙为核心，外层包覆聚多巴胺，用于递送万古霉素。该体系在酸性溶酶体环境中快速释放药物，同时在中性环境下保持稳定。体外实验表明，该纳米系统在pH 6.5时抗菌效果与游离的万古霉素相当，并且能显著提高巨噬细胞内MRSA的清除效率，为MRSA胞内感染治疗提供了新策略。
Staphylococcus aureus, particularly methicillin-resistant Staphylococcus aureus (MRSA), can evade immune clearance by invading host cells, leading to recurrent infections. Conventional antibiotics are ineffective against intracellular bacteria, prompting the development of a pH-responsive nanodelivery system in this study. The system consists of a CaCO? core coated with polydopamine (PDA) for vancomycin (Van) delivery. This system enables rapid drug release in the acidic lysosomal environment while maintaining stability under neutral conditions. In vitro experiments demonstrated that the nanosystem exhibits antibacterial efficacy comparable to free vancomycin at pH 6.5 and significantly enhances the clearance of intracellular MRSA in macrophages, offering a novel therapeutic strategy for MRSA intracellular infections.
龚泓之、贺耘
重庆大学药学院，重庆 401331重庆大学药学院，重庆 401331
医学研究方法药学基础医学临床医学
耐甲氧西林金黄色葡萄球菌胞内感染纳米载体pH响应型万古霉素
Methicillin-resistant Staphylococcus aureusintracellular infectionnanocarrierpH-responsivevancomycin
龚泓之,贺耘.pH响应型CaCO3纳米粒递送抗生素治疗胞内MRSA感染[EB/OL].(2025-04-15)[2025-05-07].http://www.paper.edu.cn/releasepaper/content/202504-141.点此复制
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