构建吲哚氮取代环戊烯酮衍生物

Indole structures are widely present in natural products and drug compounds. This paper proposes a novel synthetic method for indole derivatives. Functionalized 2-phenylacetylenylamine and 2-furaldehyde are used as substrates. Through the Br?nsted acid-catalyzed rearrangement of furaldehyde, aynyl-functionalized cyclopentenone intermediate is generated. Subsequently, the efficient synthesis of multifunctionalized indole nitrogen-substituted cyclopentenone derivatives is achieved through palladium(II) bromide (PdBr?)-catalyzed hydroamination-cyclization. This method features mild reaction conditions and high product yields, offering a new approach for the synthesis of indole derivatives and holding significant application potential.