葡聚糖功能化的金纳米棒的构建

Gold nanorods obtained by traditional preparation methods have cetyltrimethylammonium bromide (CTAB) with strong positive charge attached to the surfaces, which is highly toxic. In order to improve the biosafety of gold nanorods, dextran, as a polymer material with good biocompatibility, was used as a shell to coat gold nanorods to construct dextran-functionalized gold nanorods.The results of the size and zeta potential characterization for dextran-functionalized gold nanorods showed that they have appropriate nanosize andpotential. Meanwhile, the determination results of their ultraviolet-visible absorption spectra and heat-cooling curves indicate that they have strong light absorption ability to genearate heat, which is considered to have a good photothermal effect.Moreover, few differences between heat-cooling curves also showed the satisfactory photothermal stability. These results preliminarily demonstrate that the dextran-functionalized gold nanorods have the potential to be used as photothermal agents while ensuring biosafety, and are expected to be further developed as multifunctional medical materials.