环糊精和RAFT试剂准轮烷的合成和表征

hree novel reversible addition-fragmentation chain transfer (RAFT) agents with trithiocarbonate structures were successfully synthesized through phase-transfer, Steglich esterification, and acyl chloride methods: S-1-dodecyl-S\'-(α,α′-dimethyl-α′′-acetic acid) trithiocarbonate (DDMAT), tetraethylene glycol terminated with S-1-dodecyl-S\'-(α,α′-dimethyl-α′′-acetic acid) trithiocarbonate (TEG-CTA), and polypropylene glycol bis-terminated with S-1-dodecyl-S\'-(α,α′-dimethyl-α′′-acetic acid) trithiocarbonate (PPG-CTA). These RAFT agents were subsequently complexed with α-, β-, and γ-cyclodextrins (CDs) via co-precipitation in aqueous media to construct innovative pseudo(poly)rotaxane architectures with RAFT-initiating capabilities. Comprehensive structural characterization employing 1H NMR spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) confirmed the stable formation of all three pseudo(poly)rotaxane systems with distinct inclusion patterns and threading ratios. Notably, β-CD exhibited superior complexation behavior with PPG-CTA, demonstrating complete penetration into the central segment of the polymer chain without dissociation. This unique host-guest interaction achieved nearly full coverage of the polymer chain, indicating an optimal threading ratio. The established structure-property relationships provide valuable insights for designing advanced supramolecular RAFT systems with tailored molecular recognition features.