Reshaping MOFs text mining with a dynamic multi-agents framework of large language model

Accurately identifying synthesis conditions for metal-organic frameworks (MOFs) remains a critical bottleneck in materials research, as translating literature-derived knowledge into actionable insights is hindered by the unstructured and heterogeneous nature of scientific texts. Here we present MOFh6, a large language model (LLM)-based multi-agent system designed to extract, structure, and apply synthesis knowledge from diverse input formats, including raw literature and crystal codes. Built on gpt-4o-mini and fine-tuned with up to few-shot expert-annotated data, MOFh6 achieves 99% accuracy in synthesis data parsing and resolves 94.1% of complex co-reference abbreviations. It processes a single full-text document in 9.6 seconds and localizes structured synthesis descriptions within 36 seconds, with the cost per 100 papers reduced to USD 4.24, a 76% saving over existing systems. By addressing long-standing limitations in cross-paragraph semantic fusion and terminology standardization, MOFh6 reshapes the LLM-based paradigm for MOF synthesis research, transforming static retrieval into an integrated and dynamic knowledge acquisition process. This shift bridges the gap between scientific literature and actionable synthesis design, providing a scalable framework for accelerating materials discovery.