基于 MeVisLab的硼中子俘获治疗计划系统开发

Background] Boron Neutron Capture Therapy (BNCT) is a targeted cancer treatment integrating radiotherapy and chemotherapy, where the performance of the treatment planning system (TPS) directly determines the quality of therapeutic plans and outcomes.[Purpose] This study presents the development of a BNCT treatment planning system based on the MeVisLab platform, aiming to achieve automation, precision, and visualization in treatment planning. [Methods] The system integrates functional modules for medical image processing, dose calculation, and dose visualization, enabling efficient processing of medical imaging data (e.g., CT, MRI) and neutron dose distribution calculations through Monte Carlo simulations using OpenMC. [Results]Leveraging OpenMC's high-performance particle transport capabilities, the system accurately computes dose distributions generated by neutron interactions with boron-10 nuclei in tumor tissues, ensuring the reliability of dose calculations. Additionally, MeVisLab's modular design supports flexible algorithm extensions and customizable user operations, while providing an intuitive 3D visualization interface for physicians to design and optimize treatment plans. [Conclusions] The design and implementation of the system provides reliable technical support for the precise treatment of BNCT.