≥ 60岁人群中国内脏肥胖指数与心血管代谢性共病关系的横截面研究

Background  With the aging of the population and the increasing prevalence of multimorbidity in Chinathe high-risk characteristics of cardio-metabolic multimorbidityCMMhave become an important research field. The exact nature of the relationship between the Chinese Visceral Adiposity IndexCVAIand CMM remains to be elucidated.Objective  This study aims to investigate the relationship between theCVAIand the high risk of CMMand to evaluate the potential role of CVAI in the prevention and treatment of CMM in the elderly in China. Methods  This study was based on the data of 60 029 subjects from the Early Screening and Comprehensive Intervention of High-risk Populations of Cardiovascular Disease in Anhui Province from 2017 to 2021. The demographic informationcardiovascular health statusphysical examination and biochemical indicators were analyzedand the CVAI index was calculated. The subjects were grouped according to the quartile of CVAIand the differences in baseline characteristics were compared. Binary Logistic regression analysis was used to explore the relationship between CVAI and the high risk of CMM. The nonlinear relationship between CVAI and CMM between different genders was assessed by restricted cubic splineRCScurvesand a threshold of OR=1 was determined. Results  There were 60 029 subjectsincluding 27 203 malesCMM groupThere were 32 826 females. There were statistically significant differences in agesmokingdrinkingrural areahigh school educationbody mass indexBMImean arterial pressureMAP total cholesterolTCtriglycerideTGhigh density lipoproteinHDL-Cblood glucoseFPGdiabetesstrokehypertensionand ischemic heart disease in CVAI quartiles between different gendersP<0.05. There was no significant difference in the history of hypertension medication among males. In womenthe difference in medication history of hypertension was statistically significant multivariate. Logistic regression analysis showed that compared with T1F1 groupthe risk of CMM was significantly increased in T2 toT4F2 to F4 group. After fully adjusting for confounding factorsthe T4F4 group showed the highest risk of CMM in both sexesmaleOR=2.33595%CI=1.741-3.180P<0.001femaleOR=2.07595%CI=1.678-2.686P<0.001and femaleOR=2.73595%CI=1.778-2.686P<0.001. There was no significant difference in the odds ratio between different genders. There was no significant difference in the risk of CMM between males in T4 group and females in F4 groupZ= 0.570P=0.569. After controlling for different confounding factorsRCS curve suggested that there was a nonlinear relationship between CVAI index and CMM risk in menand the threshold of OR=1 was 94.75. There was a linear relationship between CVAI index and CMM risk in womenand the threshold of OR=1 was 114.87. Conclusion  High level of CVAI may be closely related to the risk of CMMand the predictive power is consistent in different genders. Special attention should be paid to men with CVAI over 94.75 and women with CVAI over 114.87 to reduce the risk of CMM.