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食物调整治疗抑郁症个案报告

英文摘要

epression is a common mental disorder characterized by low mood, decreased interest, and loss of energy. Its pathogenesis is complex, involving genetic, environmental, biochemical, and psychological factors. Patients with depression often exhibit a low-energy state, which is not only reflected in the core symptoms such as low mood, decreased interest, and loss of energy but may also be associated with abnormal overall energy metabolism in the body. In recent years, the "gut-brain axis" theory has shown that the gut microbiota influences mood through mechanisms such as metabolic products, neuroinflammation, and neurotransmitter regulation, and is closely related to depression. Dietary structure has a significant impact on the composition of gut microbiota, and a high-fat diet may induce depressive symptoms through various mechanisms.For patients with depression who have a preference for meat, directly switching to a diet primarily composed of low-fat fruits and vegetables may be difficult to implement. Therefore, this study attempts to explore the potential role of different types of meat in alleviating depressive symptoms and to identify which type of meat is more suitable for patients with depression, thereby providing a scientific basis for dietary intervention. Based on the characteristics of chicken being low in fat, having moderate energy content, and being rich in fast-twitch muscle fibers, this study investigates its potential role in dietary interventions for depression. Through dietary adjustment experiments with two patients with depression, allowing only chicken consumption, the results showed significant improvement in depressive symptoms, with mood stabilization and enhanced cognitive function, gastrointestinal function, and skin condition. It is analyzed that chicken may alleviate depressive symptoms and related somatic manifestations by optimizing gut microbiota balance, reducing inflammatory responses, and improving the regulation of the brain-gut-skin axis.Despite the positive results obtained, this study still has limitations, such as a small sample size and lack of strict control over other dietary components. Future research should expand the sample size, adopt a randomized controlled trial design, and combine biomarker analysis to further explore the mechanisms of chickens role in dietary interventions for depression, providing a scientific basis for optimizing the diet of patients with depression.

刘炜珊、程乐华、向润华、胡乐晨

中山大学心理学系中山大学心理学系中山大学心理学系中山大学心理学系

神经病学、精神病学皮肤病学、性病学临床医学

食物调整治疗低脂饮食抑郁症脑-肠-皮肤轴

Dietary therapyLow-fat dietepressionBrain-gut-skin axis

刘炜珊,程乐华,向润华,胡乐晨.食物调整治疗抑郁症个案报告[EB/OL].(2025-05-14)[2025-06-23].https://chinaxiv.org/abs/202505.00106.点此复制

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