氢甲酰化反应在药物合成中的应用进展

Hydroformylation is one of the most important reactions in industrial catalytic chemistry. In recent years, hydroformylation has demonstrated considerable potential in the construction of pharmaceutical molecules. This review provides a comprehensive summary of recent advances in the application of hydroformylation in drug synthesis, highlighting representative examples including vitamin A acetate, pheniramines, naproxen, omapatrilat, ibuprofen, fendiline, and various natural products. The article also identifies current challenges and limitations in this field, and proposes the development of novel, highly efficient phosphine ligands as a promising direction for future research. This work aims to offer both theoretical insights and practical guidance for the continued application of hydroformylation in pharmaceutical synthesis.