某中医院感染屎肠球菌患者的现况调查研究
Investigation and research on the Current Situation of patients infected with Enterococcus faecium in a certain Traditional Chinese Medicine Hospital
王晓蕾 1王波 1张瑜 1苏永汶 1张敏 1陈金芝1
作者信息
摘要
目的研究某中医院感染屎肠球菌患者的临床特征及其耐药情况，以期进一步降低抗生素耐药的概率。方法连续纳入自2023年1月至2032年12月期间，各临床科室感染屎肠球菌住院患者送检标本，包括尿液，血液，分泌物等，共64例。根据其药敏结果分为两组，其中耐万古霉素屎肠球菌（VRE）组26例，万古霉素敏感的屎肠球菌（VSE）组38例。根据病历，提取患者临床资料，包括性别，年龄，科室等。收集本科室的细菌鉴定及药敏结果。结果比较两组的基础资料及药敏情况。与万古霉素敏感的肠球菌组相比，万古霉素耐药肠球菌患者年龄更低。比较VRE组与VSE组的药敏结果，2组对青霉素，左旋氧氟沙星，环丙沙星，氨苄西林基本都耐药，对利奈唑胺全敏感。VRE组比VSE组对四环素，利福平耐药率更高，VRE组对四环素全耐药。VRE组比VSE组对大剂量链霉素和庆大霉素更敏感。年龄是万古霉素耐药的危险因素。结论屎肠球菌对利奈唑胺全敏感，对青霉素和氟喹诺酮类不敏感，VSE对四环素和利福平比VRE敏感。VRE对四环素全耐药，对高水平氨基糖苷类比VSE更敏感。年龄是影响屎肠球菌耐万古霉素的独立危险因素。Abstract
Objective To study the clinical characteristics and drug resistance of patients infected with Enterococcus faecium in a certain hospital of traditional Chinese medicine, in order to further reduce the probability of antibiotic resistance. Methods: From January 2023 to December 2032, specimens submitted by inpatients infected with Enterococcus faecium in various clinical departments, including urine, blood, secretions, etc., were continuously included, totaling 64 cases. According to the results of drug sensitivity, they were divided into two groups, among which there were 26 cases in the vancomycin-resistant Enterococcus faecium (VRE) group and 38 cases in the vancomycin-sensitive Enterococcus faecium (VSE) group. Based on the medical records, the clinical data of the patients were extracted, including gender, age, department, etc. Collect the bacterial identification and drug sensitivity results of this department. Result: The basic data and drug sensitivity of the two groups were compared. Compared with the vancomycin-sensitive enterococcus group, patients with vancomycin-resistant enterococcus were younger. The drug sensitivity results of the VRE group and the VSE group were compared. Both groups were basically resistant to penicillin, levofloxacin, ciprofloxacin and ampicillin, and were fully sensitive to linezolid. The VRE group had a higher resistance rate to tetracycline and rifampicin than the VSE group, and the VRE group was fully resistant to tetracycline. The VRE group was more sensitive to high-dose streptomycin and gentamicin than the VSE group. Age is a risk factor for vancomycin resistance. Conclusion: Enterococcus faecium is fully sensitive to linezolid, but not sensitive to penicillin and fluoroquinolones. VSE is more sensitive to tetracycline and rifampicin than to VRE. VRE is fully resistant to tetracycline and more sensitive to high levels of aminoglycosides than VSE. Age is an independent risk factor affecting vancomycin resistance of Enterococcus faecium. 关键词
肠球菌/万古霉素/临床特征/耐药性/危险因素Key words
Enterococcus/Vancomycin/Clinical characteristics/Drug resistance/Risk factors引用本文复制引用
王晓蕾,王波,张瑜,苏永汶,张敏,陈金芝.某中医院感染屎肠球菌患者的现况调查研究[EB/OL].(2025-05-27)[2025-12-13].http://www.paper.edu.cn/releasepaper/content/202505-160.学科分类
临床医学/基础医学/药学
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