Numerical invariants of hyper-K\"ahler manifolds

We study various constraints on the Beauville quadratic form and the Huybrechts-Riemann-Roch polynomial for hyper-K\"ahler manifolds, mostly in dimension 6 and in the presence of an isotropic class. In an appendix, Chen Jiang proves that in general, the Huybrechts-Riemann-Roch polynomial can always be written as a linear combination with nonnegative coefficients of certain explicit polynomials with positive coefficients. This implies that the Huybrechts-Riemann-Roch polynomial satisfies a curious symmetry property