银介导的自由基串联环化合成吲哚异喹啉衍生物

Nitrogen-containing heterocyclic compounds are a basic type of compounds in natural products and synthetic chemistry, playing a key role in the structure of biomolecules and drugs. Among them, polycyclic indole derivatives are an extremely important type. They are of great significance in organic synthesis and pharmaceuticals, and are widely present in drug synthesis, natural products, and various functional materials. Because indole derivatives have wide applications, they have always attracted the attention of medical and synthetic chemists. To this day, there have been many reports on the methods for synthesizing indole-derived compounds and significant achievements have been made, but several challenges still remain. Therefore, it is of great significance to continue to develop and advance simpler and more efficient synthetic methods. This paper mainly studies a silver-mediated radical addition tandem cyclization reaction, constructs polycyclic indole derivatives, and further develops the research and application of radical addition tandem cyclization reactions in heterocyclic synthesis. In the experiment, 2-aryl-N-methylacrylyl indole and α -carbonyl bromide were used as substrates. By taking advantage of the single-electron reduction property of Ag2CO3 and through free radical addition tandem cyclization, indole and [2, 1-a] isoquinoline derivatives were synthesized. In the system, apart from the reaction substrates, only silver salts and solvents are added. The reaction conditions are simple and the range of substrates is relatively wide.