新疆阿勒泰地区农牧区人群“生命八要素”评分与高血压患病风险的横断面研究

BackgroundHypertension is a major cardiovascular disease. The relationship between Life's Essential 8LE8 scorea newly developed cardiovascular health metricand hypertension risk remains unclear. ObjectiveThis study aimed to investigate the association between LE8 score and hypertension risk in the rural and pastoral population of Altay PrefectureXinjiang. MethodsFrom October to November 202327 natural villages were selected in Altay Prefecture using Proportionate to Population SizePPS systematic sampling. Eligible residents in the included natural villages were recruited for questionnaire surveysphysical examinationsand laboratory index tests. The LE8 score includes 4 health behaviorsdietphysical activitynicotine exposuresleep and 4 health factorsBMIblood lipidsblood glucoseblood pressure. In this studythe LE8 score was calculated based on the remaining 7 components excluding blood pressure. The LE8 scoresubscales and components were divided into low group0-49 pointsmedium group50-79 points and high group80-100 points according to their scores. A restrictive cubic spline plot was used to plot the dose-response curves of LE8health factors and health behavior scores and hypertension. A multivariate logistic regression model was used to analyze its effect on the prevalence of hypertension. ResultsA total of 2 872 study subjects were included in this study. Among the study subjects1 540 patients with hypertension were detectedyielding a crude prevalence of 53.62% and an age-standardized prevalence of 34.64%. The prevalence of hypertension was 61.13% in men766/1 253 and 47.81%774/1 619 in womenand the prevalence of hypertension in men was higher than that in womenP<0.05. In terms of LE8 scorethe difference between the hypertensive group and the normal blood pressure group was statistically significantP<0.05. After adjusting for confoundersthe intermediate and high LE8 score groups had a lower risk of hypertension compared with the low score groupP<0.05. For every 10-point increase in LE8 scorethe risk of hypertension decreased by 24.3% and 41.8%respectively. A significant non-linear relationship was observed between LE8 scores and hypertensionP for non-linear=0.010while a linear relationship was found between health factor scores and hypertensionP for non-linear=0.637. No significant association was observed between health behavior scores and hypertension. Participants with higher BMIblood glucoseand physical activity scores had a significantly lower risk of hypertension compared to the low-score groupP<0.05. An interaction between LE8 scores and age was detected P for interaction =0.006with a stronger effect of LE8 scores on reducing hypertension risk in individuals aged50 years. ConclusionLE8 scores are non-linearly associated with hypertension risk. Maintaining higher LE8 scores can reduce the burden of hypertensionparticularly in individuals aged 50 years.