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新型水凝胶递药系统在类风湿关节炎治疗中的应用

中文摘要英文摘要

类风湿关节炎(rheumatoid arthritis,RA)是一种严重危及患者健康的慢性、全身性自身免疫性疾病,给个人和社会造成沉重负担。治疗RA的药物种类较多,但药物治疗效果欠佳、副作用强等问题依然存在。新型水凝胶递药系统因其独特的结构与性能,如:具有良好的生物相容性、载药量大、载药方式灵活、提高药物靶向性和实现药物缓控释放,可广泛运用于RA治疗药物的递送,对RA的治疗具有积极的推动作用。本文着重阐述了用于关节腔注射的新型智能水凝胶相关研究及在RA治疗中的应用,旨在为治疗RA药物水凝胶递送系统的持续研究提供借鉴和参考。

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that seriously endangers patients\' health and imposes a heavy burden on individuals and society. Although there are many drugs for treating RA, problems such as poor therapeutic effect and strong side effects still exist. The novel hydrogel drug delivery system, with its unique structure and properties, such as good biocompatibility, large drug loading capacity, flexible drug loading methods, improved drug targeting and controlled drug release, can be widely used in the delivery of RA treatment drugs and has a positive promoting effect on the treatment of RA. This article focuses on the research of novel intelligent hydrogels for intra-articular injection and their application in the treatment of RA, aiming to provide reference and guidance for the continuous research of hydrogel drug delivery systems for RA treatment.

李颖、赵颖

重庆理工大学药学与生物工程学院,重庆 400054重庆第二师范学院生物与化学工程学院,重庆 400067

医学研究方法医学现状、医学发展

类风湿关节炎水凝胶关节腔注射研究进展

rheumatoid arthritishydrogelarticular injectionresearch progress

李颖,赵颖.新型水凝胶递药系统在类风湿关节炎治疗中的应用[EB/OL].(2025-06-27)[2025-06-30].http://www.paper.edu.cn/releasepaper/content/202506-113.点此复制

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