Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time
Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time
Plastics are essential to modern life, yet poor disposal practices contribute to low recycling rates and environmental accumulation-biological degradation and by-product reuse offer a path to mitigate this global threat. This report highlights key insights, future challenges, and research priorities identified during the CECAM workshop "Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time", held in Trieste from May 6-8, 2025. The workshop brought together an interdisciplinary community of scientists focused on advancing the sustainable use of plastics through enzyme-based degradation. A key point from the discussions is that many bottlenecks in enzymatic recycling arise not only from process engineering challenges, but also from a limited understanding of the underlying molecular mechanisms. We argue that constraints on economic viability and sustainability (e.g., harsh solvents, high temperatures, substrate crystallinity, pretreatments) can-and should-be addressed directly through enzyme design, provided these factors are understood at the molecular level, in synergy with process optimization. For this, it is essential to rely on the integration of experimental and computational approaches to uncover the molecular and mechanistic basis of enzymatic plastic degradation. We highlight how the small-format structure of the workshop, in line with the usual CECAM format, fostered a collaborative, friendly, and relaxed atmosphere. We hope this report encourages future initiatives and the formation of shared consortia to support an open, collaborative, and bio-based plastic recycling community.
Federica Bertocchini、Erik Butenschön、Emanuele Carosati、Alessia De Piero、Ania Di Pede-Mattatelli、Leonardo Faggian、Lorenzo Favaro、Pedro Alexandrino Fernandes、Alfonso Ferretti、Peter Fojan、Andreas Gagsteiger、Eva García-Ruiz、Lucia Gardossi、Toni Giorgino、Norbert Graefe、Jonas Gunkel、Diego J. Jiménez、Malene Billeskov Keller、Georg Künze、Sierin Lim、Guy Lippens、Miguel A. Maria-Solano、Karolina Mitusińska、Vicent Moliner、Gianluca Molla、Marthinus Wessel Myburgh、Nicolas Panel、César A. Ramírez-Sarmiento、Dominique Rocher、Birgit Strodel、Belén Taroncher Ruiz、Onur Turak、Cristiano Varrone、Daniele Vezzini、Peter Westh、Wolfgang Zimmermann、Francesco Colizzi、Paula Blázquez-Sánchez、Giovanni Bussi、Isabelle André、Federico Ballabio、Thomas Bayer
废物处理、废物综合利用生物科学研究方法、生物科学研究技术分子生物学环境科学理论生物工程学
Federica Bertocchini,Erik Butenschön,Emanuele Carosati,Alessia De Piero,Ania Di Pede-Mattatelli,Leonardo Faggian,Lorenzo Favaro,Pedro Alexandrino Fernandes,Alfonso Ferretti,Peter Fojan,Andreas Gagsteiger,Eva García-Ruiz,Lucia Gardossi,Toni Giorgino,Norbert Graefe,Jonas Gunkel,Diego J. Jiménez,Malene Billeskov Keller,Georg Künze,Sierin Lim,Guy Lippens,Miguel A. Maria-Solano,Karolina Mitusińska,Vicent Moliner,Gianluca Molla,Marthinus Wessel Myburgh,Nicolas Panel,César A. Ramírez-Sarmiento,Dominique Rocher,Birgit Strodel,Belén Taroncher Ruiz,Onur Turak,Cristiano Varrone,Daniele Vezzini,Peter Westh,Wolfgang Zimmermann,Francesco Colizzi,Paula Blázquez-Sánchez,Giovanni Bussi,Isabelle André,Federico Ballabio,Thomas Bayer.Computations Meet Experiments to Advance the Enzymatic Depolymerization of Plastics One Atom at a Time[EB/OL].(2025-07-18)[2025-08-16].https://arxiv.org/abs/2507.14413.点此复制
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