2000—2024年神经系统疾病与肠道菌群关系研究变化情况的可视化分析

BackgroundNeurological disorders severely impact patients' quality of life. These disorders have multifactorial etiologiesincluding geneticinfectiousand immunological factors. Emerging evidence highlights the role of gut microbiota in these disorders through the gut-brain axis. Howeverthe research hotspots and trends in this field remain inadequately characterized. ObjectiveThis study aims to conduct a visual analysis of the literature related to neurological disorders and gut microbiotawith the goal of understanding the current research landscape both domestically and internationally. Furthermoreit seeks to explore the research hotspots and emerging trendsthereby providing a reference for future studies. MethodsRelevant literature was retrieved from the Web of Science Core Collection database from January 12000 to July 292024. Using CiteSpace softwarea visual analysis was performed from multiple aspectsincluding publication volumeco-citation analysishighly cited paperscitation burst paperskeyword co-occurrencenational collaborationinstitutional collaborationand author collaboration. ResultsA total of 5 239 articles were includedwith a steady increase in publication volume since 2012surpassing 1 000 articles in 2022. The research hotspots primarily concentrate on Parkinson's diseaseAlzheimer's diseaseischemic strokeand amyotrophic lateral sclerosis. Citation analysis reveals that the relationship between gut microbiota and CNS diseases has become a prominent research focus in recent years. Moreoverco-occurrence analysis of keywords further highlights the frequent appearance of important research topics such as short-chain fatty acidsthe gut-brain axisand gut microbiota dysbiosisindicating a high level of attention to these areas. High-citation articles and citation burst analysis show that the research trend is centered on the mechanisms through which gut microbiota influence neurodegenerative diseases and other CNS disordersparticularly focusing on the regulatory roles of short-chain fatty acidsgut microbiota diversityand the gut-brain axis. ConclusionCiteSpace-based bibliometric analysis suggests a potential association between gut microbiota and neurological disorders such as Parkinson's diseaseAlzheimer's diseaseand multiple sclerosis. Modulation of gut microbiota may offer a promising therapeutic avenue for the management of these conditions. Further longitudinal studies and clinical trials are warranted to validate this hypothesis and to elucidate the underlying mechanisms by which the gut microbiota influences neurological disease pathogenesis.