CURE: Confidence-driven Unified Reasoning Ensemble Framework for Medical Question Answering
Ziad Elshaer Essam A. Rashed
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Abstract
High-performing medical Large Language Models (LLMs) typically require extensive fine-tuning with substantial computational resources, limiting accessibility for resource-constrained healthcare institutions. This study introduces a confidence-driven multi-model framework that leverages model diversity to enhance medical question answering without fine-tuning. Our framework employs a two-stage architecture: a confidence detection module assesses the primary model's certainty, and an adaptive routing mechanism directs low-confidence queries to Helper models with complementary knowledge for collaborative reasoning. We evaluate our approach using Qwen3-30B-A3B-Instruct, Phi-4 14B, and Gemma 2 12B across three medical benchmarks; MedQA, MedMCQA, and PubMedQA. Result demonstrate that our framework achieves competitive performance, with particularly strong results in PubMedQA (95.0\%) and MedMCQA (78.0\%). Ablation studies confirm that confidence-aware routing combined with multi-model collaboration substantially outperforms single-model approaches and uniform reasoning strategies. This work establishes that strategic model collaboration offers a practical, computationally efficient pathway to improve medical AI systems, with significant implications for democratizing access to advanced medical AI in resource-limited settings.引用本文复制引用
Ziad Elshaer,Essam A. Rashed.CURE: Confidence-driven Unified Reasoning Ensemble Framework for Medical Question Answering[EB/OL].(2025-10-16)[2026-04-02].https://arxiv.org/abs/2510.14353.学科分类
医学现状、医学发展/医学研究方法
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