四链DNA倒锥形风车模型的构建与生物学意义初探
Construction and Biological Significance of Four stranded DNA Inverted Cone Windmill Model
摘要
基于钾离子通道折纸风车模型的结构启发，结合DNA分子的多链折叠特性、离子调控机制及遗传信息传递规律，提出四链DNA倒锥形风车模型，突破传统双螺旋模型的线性结构局限。该模型以四链DNA为核心骨架，通过“双梯倒扣”形成类风车的辐射状空间构象，链间通过氢键、碱基堆积作用及离子调控稳定，同时依托“单梯遗传”机制实现遗传信息的精准传递。本文详述模型的构建溯源、结构特征、遗传机制及潜在生物学意义，为DNA多链结构与遗传调控研究提供新视角。Abstract
Inspired by the structure of the potassium channel origami windmill model, and combining the multi-strand folding characteristics of DNA molecules, ion regulation mechanisms, and genetic information transmission rules, a four-strand DNA inverted cone windmill model is proposed, breaking through the linear structural limitations of the traditional double helix model.The model utilizes a four-stranded DNA core scaffold, forming a windmill-like radial spatial conformation through a “double ladder inverted” mechanism. The strands are stabilized by hydrogen bonding, base stacking, and ionic regulation, while relying on the “single ladder inheritance”mechanism to achieve precise transmission of genetic information. This article elaborates on the construction lineage, structural characteristics, genetic mechanism, and potential biological significance of the model, providing a new perspective for the study of DNA multi-strand structure and genetic regulation. 
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