不同频率振腹推拿干预糖耐量异常大鼠胰岛素抵抗的量效研究
Dose-Effect Relationship of Different Frequencies of Abdominal Vibration Massage on Insulin Resistance in Rats with Impaired Glucose Tolerance
闫阔 1姚斌彬 1刘杨 2周淳浩 1付春雨 1赵子刚 1李金龙1
作者信息
- 1. 北京中医药大学针灸推拿学院，北京 102488
- 2. 北京中医药大学东方医院，北京 100078
- 折叠
摘要
目的：探讨400次/min、500次/min、600次/min振腹推拿对糖耐量异常（IGT）大鼠糖代谢及胰岛素抵抗（IR）的改善作用，并明确其优势频率。方法：将30只SD大鼠分为正常组、IGT组、400振腹组、500振腹组和600振腹组，每组6只。采用高脂饮食联合小剂量链脲佐菌素建立IGT模型，各振腹组每日于神阙穴接受相应频率干预20分钟，连续7天。检测空腹血糖（FPG）、餐后2小时血糖（2hPG）、空腹胰岛素（FINS）并计算胰岛素抵抗指数（HOMA-IR），观察胰腺病理形态。结果：与正常组相比，IGT组FPG、2hPG、FINS及HOMA-IR均显著升高（P<0.05），胰岛结构受损。振腹干预后，各频率组指标均有改善，其中400振腹组FPG显著降低（P<0.05），FINS与HOMA-IR恢复至近正常水平，胰岛形态改善最明显；600振腹组体质量增长受控（P<0.05）；500及600振腹组改善作用相对有限。结论：振腹推拿可改善IGT大鼠糖代谢异常与IR，且具有频率依赖性，400次/min为优势频率，其机制可能与增强胰岛素敏感性有关。
Abstract
Objective: To investigate the effects of abdominal vibration massage at frequencies of 400, 500, and 600 times/min on glucose metabolism and insulin resistance (IR) in rats with impaired glucose tolerance (IGT), and to identify the optimal frequency. Methods: Thirty SD rats were divided into a normal control group, an IGT model group, and three vibration groups (400, 500, and 600 times/min), with 6 rats per group. The IGT model was established using a high-fat diet combined with a low-dose streptozotocin injection. The vibration groups received daily 20-minute interventions at the corresponding frequency on the Shenque (CV8) acupoint for 7 consecutive days. Fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), and fasting insulin (FINS) levels were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Pancreatic histopathology was also observed. Results: Compared with the normal group, the IGT group showed significant increases in FPG, 2hPG, FINS, and HOMA-IR (P<0.05), along with islet structural damage. After vibration intervention, all frequency groups exhibited varying degrees of improvement. The 400 times/min group showed a significant reduction in FPG (P<0.05), with FINS and HOMA-IR returning to near-normal levels, and demonstrated the most pronounced improvement in islet morphology. The 600 times/min group showed controlled body weight gain (P<0.05). The improvements in the 500 and 600 times/min groups were relatively limited. Conclusion: Abdominal vibration massage can improve glucose metabolism abnormalities and IR in IGT rats, with its effects being frequency-dependent. A frequency of 400 times/min appears to be the optimal parameter in this study, potentially exerting its core regulatory effect by enhancing insulin sensitivity.关键词
糖耐量异常、振腹推拿、频率、胰岛素抵抗Key words
Impaired Glucose Tolerance/Abdominal Vibration Massage/Frequency/Insulin Resistance引用本文复制引用
闫阔,姚斌彬,刘杨,周淳浩,付春雨,赵子刚,李金龙.不同频率振腹推拿干预糖耐量异常大鼠胰岛素抵抗的量效研究[EB/OL].(2026-02-12)[2026-02-14].http://www.paper.edu.cn/releasepaper/content/202602-73.学科分类
生理学
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