Prototype of a real-time three-dimensional dosimetric imaging system for particle therapy
Prototype of a real-time three-dimensional dosimetric imaging system for particle therapy
Zhiguo Xu 1Xinle Lang 1Jiali Fu 1Weilong Li 2Ruishi Mao 1Guoqing Xiao 1Faming Luo 1Chuan Huang 2Zhengguo Hu 1Yucong Chen 2Xiuling Zhang 2Juan Li 2Xincai Kang 2Zulong Zhao 2Kai Zhou 2Xiaotao Liu2
作者信息
- 1. School of Nuclear Science and Technology, University of Chinese Academy of Sciences;Institute of Modern Physics, Chinese Academy of Sciences
- 2. Institute of Modern Physics, Chinese Academy of Sciences
- 折叠
摘要
粒子放射治疗相较于光子放射治疗具有独特的物理和生物学优势。然而，其治疗过程中仍存在诸多不确定性来源，如摆位误差、射程涨落、入射粒子误差以及其他因素。这些不确定性的识别与控制对于实现更精准的治疗、减少患者接受不必要或过量剂量具有重要意义。降低治疗不确定性的关键途径之一是实施三维（3D）剂量学。因此，开发一种能够在治疗递送过程中对患者体内剂量进行三维重建的独立技术，对于粒子治疗中心而言至关重要。本研究旨在开发一种用于粒子治疗的实时三维剂量成像系统，以监测粒子治疗过程中患者体内的束流射程和剂量分布。研究设计并评估了该成像系统的原型，该原型由束流监测系统和剂量引擎（DoRT）组成。束流监测系统用于在治疗过程中实时测量笔形束参数，DoRT则用于重建目标区域内笔形束的三维剂量分布。我们在重离子医学装置（HIMM）上，采用入射碳离子对该原型系统进行了功能评估，并将其重建得到的剂量分布与蒙特卡罗计算结果及胶片测量结果进行了比较。针对所研究的锯齿形扫描递送案例，该原型系统实现了体素尺寸为1 mm立方的实时剂量重建，单个笔形束剂量分布的重建时间为46 ms。将重建剂量与蒙特卡罗模拟结果进行基准比较后发现，其平均Gamma通过率（3 mm，3%）为95.36%。此外，重建得到的横向剂量剖面分布与医用胶片测量结果吻合良好，剂量偏差中位数为1.56%。这些实验结果证实了该系统用于三维剂量成像的可行性。本研究实现了粒子治疗中的实时三维剂量重建，其最终目标是为实时三维剂量成像提供一种新的参考方案，从而提高粒子治疗的准确性。
Abstract
Particle radiotherapy offers unique physical and biological advantages over photon radiotherapy. However, it shows numerous uncertainties due to positioning errors, range straggling, incident particle errors, and other factors. Addressing and mitigating these uncertainties can lead to more precise treatment and reduce the unnecessary or excessive doses administered to patients. A critical approach to reducing uncertainties in treatment is the implementation of three-dimensional (3D) dosimetry. Thus, developing an independent technique for 3D dose reconstruction in patients during treatment delivery is crucial for particle therapy facilities. In this study, we aimed to develop a real-time 3D dosimetric imaging system for particle therapy to monitor the beam range and dose distribution in patients during particle therapy. A prototype of the imaging system was designed and evaluated using a beam-monitoring system and dose engine (DoRT). The beam-monitoring system was used to measure the parameters of a pencil beam in real-time during treatment, and DoRT was used to reconstruct the 3D dose distribution of the pencil beam in the target. We performed a functional evaluation of this prototype with carbon ions incident on a heavy-ion medical machine (HIMM) and compared the reconstructed dose distribution with those obtained from Monte Carlo calculations and film measurements. For the investigated zigzag-scanning delivery case, real-time dose reconstruction with 1 mm cubic voxels was achieved by this prototype, and the time required to reconstruct the dose distribution of an individual pencil beam was 46 ms. The reconstructed doses were benchmarked against Monte Carlo simulated results, where the average gamma index passing rate (3 mm, 3%) was 95.36%. In addition, the reconstructed lateral profile dose distributions were in good agreement with the medical film measurement results, and the median value of the dose deviation was 1.56%. These experimental results confirm the feasibility of the system for 3D dosimetric imaging. In this study, real-time 3D dose reconstruction for particle therapy is realized with the ultimate goal of providing a new reference scheme for real-time 3D dosimetric imaging to improve the accuracy of particle therapy.关键词
粒子治疗/实时剂量成像/三维剂量重建/质量保证/笔形束Key words
Particle therapy/Real-time dosimetric imaging/3D dose reconstruction/Quality assurance/Pencil beam引用本文复制引用
Zhiguo Xu,Xinle Lang,Jiali Fu,Weilong Li,Ruishi Mao,Guoqing Xiao,Faming Luo,Chuan Huang,Zhengguo Hu,Yucong Chen,Xiuling Zhang,Juan Li,Xincai Kang,Zulong Zhao,Kai Zhou,Xiaotao Liu.Prototype of a real-time three-dimensional dosimetric imaging system for particle therapy[EB/OL].(2026-03-17)[2026-03-19].https://chinaxiv.org/abs/202603.00086.学科分类
肿瘤学/基础医学/自动化技术、自动化技术设备
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