载脂蛋白J在代谢性疾病中的研究进展
Advances in Research on Apolipoprotein J in Metabolic Diseases
王加伟 1邓霞 1袁国跃1
作者信息
- 1. 212001 江苏省镇江市，江苏大学附属医院内分泌代谢科 江苏大学内分泌代谢病研究院
- 折叠
摘要
代谢性疾病严重影响全球公共卫生健康。载脂蛋白J（ApoJ）是一种广泛表达于大脑、肝脏和睾丸等器官的多功能糖蛋白，参与维持蛋白质稳态、调控细胞凋亡等生理病理过程。近年来研究发现，ApoJ与胰岛素抵抗、脂质代谢、炎症反应等过程密切相关，参与糖尿病、肥胖症等代谢性疾病的发生、发展。本文系统综述ApoJ在2型糖尿病、动脉粥样硬化性心血管疾病、肥胖症、代谢功能障碍相关脂肪性肝病及多囊卵巢综合征中的研究进展，重点阐述其在疾病中的表达水平变化及分子作用机制，进而探讨了以ApoJ作为代谢性疾病新型生物标志物和干预靶点的潜力，同时对比分析了其在不同疾病中功能表现的差异及可能原因，旨在为ApoJ与代谢性疾病的基础研究及临床应用提供一定的参考。
Abstract
Metabolic diseases present a substantial challenge to global public health. Apolipoprotein J (ApoJ), a multifunctional glycoprotein widely expressed in organs including the brain, liver, and testes, participates in essential physiological and pathological processes such as maintaining protein homeostasis and regulating apoptosis. Recent investigations have established that ApoJ is closely associated with fundamental metabolic processes including insulin resistance, lipid metabolism, and inflammatory responses, thereby contributing to the pathogenesis of metabolic disorders such as diabetes and obesity. This article systematically reviews the research progress on ApoJ in type 2 diabetes, atherosclerotic cardiovascular disease, obesity, metabolic dysfunction-associated steatotic liver disease, and polycystic ovary syndrome. It focuses on elucidating the alterations in its expression levels and the underlying molecular mechanisms of action across these diseases, thereby exploring the potential of ApoJ as a novel biomarker and therapeutic target for metabolic disorders. Furthermore, the article compares and analyzes the differences in its functional manifestations among various diseases and discusses the possible reasons behind them. This review aims to provide a reference for both basic research and clinical applications concerning ApoJ in metabolic diseases.关键词
载脂蛋白 J/代谢疾病/糖尿病，2 型/动脉粥样硬化/心血管疾病/肥胖症/代谢功能障碍相关脂肪性肝病/多囊卵巢综合征引用本文复制引用
王加伟,邓霞,袁国跃.载脂蛋白J在代谢性疾病中的研究进展[EB/OL].(2026-03-19)[2026-03-21].https://chinaxiv.org/abs/202603.00106.学科分类
医药卫生理论/医学现状、医学发展/医学研究方法/基础医学/内科学
评论