抗菌肽结构衍生的研究进展：从化学修饰到理性设计
Research Progress in Structural Derivation of Antimicrobial Peptides: From Chemical Modification to Rational Design
王欣雨 1徐景悦 1黄欣然 1胡文丽 1王梦 1贾希灿 1杨佳婷 1汪燕 1穆秋起1
作者信息
- 1. 黄山学院化学化工学院，黄山 245041
- 折叠
摘要
为提升抗菌肽的成药性以应对严峻的细菌耐药性问题，对其结构进行理性衍生至关重要。本文系统综述了抗菌肽结构衍生修饰的三大主流策略：通过直接修饰肽链骨架以优化性质的主链末端修饰、对氨基酸侧链进行精准或全局改造的侧链修饰，以及基于构效关系进行可预测编程的理性设计。总结了三类方法的原理、应用实例与局限。最后展望了融合人工智能与新型理性设计工具，将推动抗菌肽研发从经验筛选迈向可预测、可编程的新范式，为开发高效低毒的新型抗菌肽提供参考。
Abstract
To enhance the druggability of antimicrobial peptides (AMPs) in response to bacterial drug resistance, rational structural derivation of AMPs is of critical importance. This paper systematically reviews three mainstream strategies in this field: main-chain end modification, which involves direct modification of the peptide backbone to optimize properties; side-chain modification, which entails precise or global modification of amino acid side chains; and rational design based on structure-activity relationships for predictable programming. The principles, application examples, and limitations of these three methods are summarized. Finally, it is anticipated that the integration of artificial intelligence with novel rational design tools will propel the development of AMPs from empirical screening to a predictable and programmable paradigm, providing references for the development of novel and highly effective AMPs with low-toxicity.关键词
抗菌肽/结构衍生/主链末端修饰/侧链修饰/理性设计Key words
kantimicrobial peptides/structural derivation/main-chain end modification/side-chain modification/rational design引用本文复制引用
王欣雨,徐景悦,黄欣然,胡文丽,王梦,贾希灿,杨佳婷,汪燕,穆秋起.抗菌肽结构衍生的研究进展：从化学修饰到理性设计[EB/OL].(2026-03-26)[2026-03-27].http://www.paper.edu.cn/releasepaper/content/202603-259.学科分类
医学研究方法/生物科学现状、生物科学发展/生物科学研究方法、生物科学研究技术/药学
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