首页|Comparative Study of Biomarkers (PCT, Interleukin-6, Lactate) in Assessing Disease Severity and Organ Dysfunction in Patients with Septic Shock
Comparative Study of Biomarkers (PCT, Interleukin-6, Lactate) in Assessing Disease Severity and Organ Dysfunction in Patients with Septic Shock
张怀伟 王冰 陈燕 王炜林 谷美 李萌启 宋晓庆 彭岩
国家预印本平台Comparative Study of Biomarkers (PCT, Interleukin-6, Lactate) in Assessing Disease Severity and Organ Dysfunction in Patients with Septic Shock
Abstract
To investigate the correlations of procalcitonin (PCT), interleukin-6 (IL-6), and lactate (Lac) with disease severity (assessed by APACHE II score) and organ dysfunction in patients with septic shock, and to compare their predictive values. Clinical data of 61 patients with septic shock were retrospectively analyzed. Spearman correlation analysis was used to evaluate the relationships of PCT, IL-6, and Lac with APACHE II scores and organ function indicators (creatinine, platelet count, ALT). The predictive abilities of these biomarkers for 28-day mortality were compared using receiver operating characteristic (ROC) curve analysis, and multivariate logistic regression was employed to assess their independent predictive value. Lactate showed the strongest correlation with APACHE II scores and was significantly associated with renal dysfunction and coagulopathy. PCT exhibited a moderate correlation with APACHE II scores and was linked to liver injury. IL-6 had a weak correlation with APACHE II scores and no significant association with organ function indicators. ROC analysis revealed that lactate had the largest area under the curve (AUC) for predicting 28-day mortality, with an optimal cutoff value of 7.6 mmol/L (sensitivity 90.9%, specificity 82.0%). Its predictive performance was significantly superior to that of PCT (AUC = 0.608) and IL-6 (AUC = 0.670). Multivariate regression analysis identified a lactate level >7.6 mmol/L as an independent risk factor for 28-day mortality. Among PCT, IL-6, and lactate, lactate demonstrates the strongest association with overall disease severity and organ dysfunction (particularly renal and coagulation impairments) in septic shock patients and serves as an independent predictor of short-term prognosis, offering the highest predictive value. Thus, lactate should be considered a core biomarker for assessing critical illness and prognosis in septic shock.Key words
Septic shock/ Procalcitonin (PCT)/ Interleukin-6 (IL-6)/ APACHE II score/ Prognosis引用本文复制引用
张怀伟,王冰,陈燕,王炜林,谷美,李萌启,宋晓庆,彭岩.Comparative Study of Biomarkers (PCT, Interleukin-6, Lactate) in Assessing Disease Severity and Organ Dysfunction in Patients with Septic Shock[EB/OL].(2026-04-13)[2026-04-17].https://sinoxiv.napstic.cn/article/25749045.学科分类
医学研究方法基金
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