儿童肥胖与智力之间的因果关系：一项孟德尔随机研究
Causal relationship between childhood obesity and intelligence: A Mendelian randomization study
李元枭 1张妮 1徐晓楠 1李艳 1成利 1刘慧 1戴星星 1任鹏程 1马汉伟1
作者信息
摘要
背景儿童肥胖已成为影响儿童身心健康的普遍公共卫生问题，受到社会的广泛关注。然而，儿童肥胖是否会影响儿童的智力仍然未知。本研究旨在探讨儿童肥胖与儿童智力之间的因果关系。方法 从最大的儿童肥胖全基因组关联研究（GWAS）（住院与人群）（5530例和8318例欧洲血统对照）中选择了6个独立的儿童肥胖遗传工具变异（IVs）。使用最大的儿童智力GWAS （n = 12441名欧洲血统的个体）来评估已确定的儿童肥胖相关基因IVs对儿童智力的影响。结果 mr-egger检验结果显示，儿童肥胖与儿童智力之间没有显著的因果关系（β =-0.261；P =0.376；比值比（OR）=0.770；95%置信区间（CI）：0.470~1.262）、简单模式（β=0.002；P= 0.969；OR=1.003；95% CI：0.885~1.136）、加权模式（β=0.006；P=0.922；OR=1.006；95% CI：0.897~1.128)、加权中位数（β=-0.009；P=0.827；OR=0.991；95% CI：0.912~1.076）和IVW（β=-0.030；P=0.370；OR=0.971；95% CI：0.910~1.036）。结论本研究未发现遗传易感性导致的儿童肥胖与儿童智力之间存在显著的因果关系。
Abstract
Background Childhood obesity has become a prevalent public health issue affecting the physical and mental well-being of children, drawing widespread societal concern. However, whether childhood obesity impacts children\'s intelligence remains unknown. This study aims to investigate the causal relationship between childhood obesity and childhood intelligence.Methods Six independent genetic instrumental variables (IVs) for childhood obesity were selected from the largest genome-wide association study (GWAS) of childhood obesity (inpatient and population-based) (5,530 cases and 8,318 controls of European ancestry). The largest GWAS for childhood intelligence (n = 12,441 individuals of European ancestry) was used to assess the effect of the identified childhood obesity-related genetic IVs on childhood intelligence.Results MR-Egger regression analysis showed no significant causal relationship between childhood obesity and childhood intelligence (β = -0.261; P = 0.376; Odds Ratio (OR) = 0.770; 95% Confidence Interval (CI): 0.470-1.262). Similar null results were observed using the simple mode (β = 0.002; P = 0.969; OR = 1.003; 95% CI: 0.885-1.136), weighted mode (β = 0.006; P = 0.922; OR = 1.006; 95% CI: 0.897-1.128), weighted median (β = -0.009; P = 0.827; OR = 0.991; 95% CI: 0.912-1.076), and inverse-variance weighted (IVW) methods (β = -0.030; P = 0.370; OR = 0.971; 95% CI: 0.910-1.036). Conclusion This study found no significant causal relationship between genetically predicted childhood obesity and childhood intelligence.关键词
儿童肥胖/儿童智力/孟德尔随机化/遗传变异/全基因组关联研究Key words
Childhood Obesity/Childhood Intelligence/Mendelian Randomization/Genetic Variation/Genome-Wide Association Study引用本文复制引用
李元枭,张妮,徐晓楠,李艳,成利,刘慧,戴星星,任鹏程,马汉伟.儿童肥胖与智力之间的因果关系：一项孟德尔随机研究[EB/OL].(2026-05-09)[2026-05-10].http://www.paper.edu.cn/releasepaper/content/202605-26.学科分类
医学研究方法/遗传学/儿科学
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