Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy
Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy
Aditi Sonone 1Mansi Thakur 1Sagar Trivedi 1Sapna Patel 2Manisha Kawadkar 1Kamlesh Wadhera1
作者信息
- 1. School of Pharmacy, G H Raisoni University, Saikheda, Madhya Pradesh 480337, India
- 2. KDK College of Pharmacy & Research Institute, Maharashtra 440009, India
- 折叠
摘要
The most virulent primary brain cancer is Glioblastoma Multiforme (GBM), which is defined mainly by poor survival and drug delivery failure as a therapy. The blood-brain barrier (BBB) restricts the passage of nearly all macromolecular drugs. The presence of a heterogeneous blood-tumor barrier (BTB) at invasive fronts is primarily accountable for recurrence location. This review helps in understanding the key role of CPP-functionalized Nanocarriers (NCs) in effective brain tumor targeting and crossing biological barriers. Conjugation of CPPs with NCs facilitates receptor-mediated transcytosis across the BBB and allows efficient endosomal release and targeted intracellular delivery within GBM cells and drug-resistant Glioma Stem Cells (GSCs). In addition, the review evaluates the hybrid platforms including CPP-liposomes, polymeric NCs, Dendrimers, and Inorganic NCs that utilize dual targeting and stimulus-responsive activation approaches for targeted delivery and synergy. Increased brain uptake and drug delivery by using the CPPs conjugated NCs are being viewed in preclinical studies. The novel synergy of peptide engineering and nanotechnology holds a distinctive potential to overcome both therapeutic resistance and delivery constraint, enabling efficient, personalized GBM nanomedicine.
Abstract
The most virulent primary brain cancer is Glioblastoma Multiforme (GBM), which is defined mainly by poor survival and drug delivery failure as a therapy. The blood-brain barrier (BBB) restricts the passage of nearly all macromolecular drugs. The presence of a heterogeneous blood-tumor barrier (BTB) at invasive fronts is primarily accountable for recurrence location. This review helps in understanding the key role of CPP-functionalized Nanocarriers (NCs) in effective brain tumor targeting and crossing biological barriers. Conjugation of CPPs with NCs facilitates receptor-mediated transcytosis across the BBB and allows efficient endosomal release and targeted intracellular delivery within GBM cells and drug-resistant Glioma Stem Cells (GSCs). In addition, the review evaluates the hybrid platforms including CPP-liposomes, polymeric NCs, Dendrimers, and Inorganic NCs that utilize dual targeting and stimulus-responsive activation approaches for targeted delivery and synergy. Increased brain uptake and drug delivery by using the CPPs conjugated NCs are being viewed in preclinical studies. The novel synergy of peptide engineering and nanotechnology holds a distinctive potential to overcome both therapeutic resistance and delivery constraint, enabling efficient, personalized GBM nanomedicine.关键词
Blood-Brain Barrier/Transcytosis/Endosomal Escape/Glioma/Stem Cells/Stimuli-Responsive/Angiopep-2Key words
Blood-Brain/Barrier/Transcytosis/Endosomal Escape/Glioma/Stem Cells/Stimuli-Responsive/Angiopep-2引用本文复制引用
Aditi Sonone,Mansi Thakur,Sagar Trivedi,Sapna Patel,Manisha Kawadkar,Kamlesh Wadhera.Cell-penetrating peptides as a gateway for nanocarrier-mediated glioblastoma therapy[EB/OL].(2026-07-09)[2026-07-11].https://chinaxiv.org/abs/202607.00073.学科分类
肿瘤学/医药卫生理论
