癫痫脑深部电刺激治疗的全球趋势、临床应用与前沿靶点策略 基于双数据库的 2004—2024 年文献计量分析及 2025—2026 年前瞻性洞察
张泽书 宝福凯 杨振兴 郜彩斌 黄德俊
癫痫脑深部电刺激治疗的全球趋势、临床应用与前沿靶点策略 基于双数据库的 2004—2024 年文献计量分析及 2025—2026 年前瞻性洞察
Global trends, clinical applications and emerging targeting strategies of deep brain stimulation for epilepsy: A dual-database bibliometric analysis (2004–2024) with an updated analysis of 2025–2026 research
Abstract
Abstract Background Epilepsy is one of the most prevalent and disabling chronic neurological disorders worldwide, affecting approximately 79 million individuals. As a customizable and reversible neuromodulatory intervention, deep brain stimulation (DBS) has revolutionized the clinical management of drug-resistant epilepsy (DRE). Despite its expanding clinical application, there remains a lack of systematic, data-driven integrated research on the global development trajectory and target-specific advances in the field of DBS for epilepsy. This study aims to quantitatively map the 20-year academic landscape of this field and identify current clinical frontier directions. Methods This study represents the first dual-database bibliometric analysis in this domain, cross-validating 1,595 publications from the Web of Science Core Collection (WoSCC) and 1,696 publications from the Scopus database covering the period 2004 to 2024. Knowledge mapping and visualization were performed using VOSviewer (v1.6.20) and CiteSpace (v6.4.R1). To capture recent developments, we additionally screened 502 publications from January 2025 to May 2026 and conducted a focused supplementary analysis of 144 influential recent publications meeting prespecified citation- or journal-based criteria. Results Global publication output demonstrated a sustained upward trend from 2004 to 2024, with annual publications increasing substantially over the study period. The growth trajectory reflected continued expansion of research activity in DBS for epilepsy, accompanied by increasing international collaboration and diversification of clinical targets, with the United States, China and Germany ranking as the top three most productive countries. The academic evolution of the field falls into three distinct phases: an early target exploration phase (2004–2012), a technological iteration and clinical evidence accumulation phase (2013–2018), and a rapid development phase of network modulation and adaptive systems (2019–2024). Frontier literature from 2025 to 2026 identifies five core development directions: ① closed-loop and AI-driven adaptive neuromodulation is progressing toward clinical translation; ② connectome-guided novel targeting strategies are continuously emerging; ③ advances in minimally invasive and non-invasive neuromodulation technologies are providing complementary technical and mechanistic insights for the development of DBS; ④ mechanistic research is increasingly guiding clinical parameter optimization; ⑤ DBS indications are expanding to pediatric populations, with further validation of long-term safety profiles. Conclusions This study systematically delineates the 20-year intellectual landscape of DBS for epilepsy and integrates up-to-date prospective insights. It provides a systematic reference and an updated reference for clinicians and researchers to grasp the evolutionary trajectory of the field and identify priority directions for future investigation.Key words
Deep brain stimulation/ Drug-resistant epilepsy/ Clinical neuromodulation/ Target selection/ Bibliometrics/ Prospective insights引用本文复制引用
张泽书,宝福凯,杨振兴,郜彩斌,黄德俊.癫痫脑深部电刺激治疗的全球趋势、临床应用与前沿靶点策略 基于双数据库的 2004—2024 年文献计量分析及 2025—2026 年前瞻性洞察[EB/OL].(2026-11-09)[2026-11-10].https://sinoxiv.napstic.cn/article/26468087.学科分类
外科学基金
重点研发计划 脑卒中后遗症患者个体化立体定向经颅磁刺激神经智能调控设备研发( 2026BEG02008 )