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川芎活性成分在骨质疏松及骨整合中的应用研究进展
Research Progress on the Application of Chuanxiong Active Ingredients in Osteoporosis and Osseointegration
摘要
川芎嗪和阿魏酸作为传统活血化瘀中药川芎的主要活性成分，在近年被广泛应用于骨代谢调控中并得到越来越多的关注，已有关于两者在体外细胞实验、动物模型以及信号通路上对其抗骨质疏松和促成骨的药理作用进行了初步探索，但是尚未有综述对其进行整合总结。因此，本文将以川芎嗪和阿魏酸为两条分子线索，沿着促成骨分化与抗骨质疏松、抑制破骨细胞活化、促血管新生与骨整合协同三条功能方向，对2016—2026近年来关于这两类药物的相关研究进行检索及归纳；梳理了它们通过OPG/RANKL/RANK、NF-κB、MAPK、BMP-2/Smad、Wnt/β-catenin和Nrf2/ARE等信号通路来调节骨代谢的研究进展，讨论了二者的以成骨细胞源性的RANKL/OPG来调节和直接RANKL-RANK的信号阻断这两种模式互补地调控破骨细胞的信号网络，同时归纳了他们在骨组织工程支架和植入体表面的功能化上的应用进展。在此基础上，本文进一步分析川芎嗪与阿魏酸协同效应评价、促血管新生与成骨耦联机制、植入体骨整合大动物模型证据、体内释放动力学及长期安全性等方面尚待解决的问题，提出其向临床骨整合应用转化过程中需要关注的协同效应定量评价、血管新生—成骨耦联因果关系验证及可控递送体系设计等关键方向。
Abstract
As the main active ingredients of traditional blood-activating and stasis-resolving medicine Chuanxiong, Ligustrazine and Ferulic Acid have been widely applied in bone metabolism regulation in recent years and have received increasing attention. Preliminary explorations have been conducted on their pharmacological effects in anti-osteoporosis and osteogenesis promotion through in vitro cell experiments, animal models, and signaling pathways, but no review has integrated and summarized them yet. Therefore, this paper takes ligustrazine and ferulic acid as two molecular clues, along three functional directions of promoting osteogenic differentiation and anti-osteoporosis, inhibiting osteoclast activation, and promoting angiogenesis and osseointegration synergy, to retrieve and summarize the relevant studies on these two drugs from 2016 to 2026; it reviews the research progress of their regulation of bone metabolism through signaling pathways such as OPG/RANKL/RANK, NF-κB, MAPK, BMP-2/Smad, Wnt/β-catenin, and Nrf2/ARE, discusses how their two modes of complementing each other to regulate the osteoclast signaling network—regulation by osteoblast-derived RANKL/OPG and direct RANKL-RANK signal blockade—and summarizes their application progress in the functionalization of bone tissue engineering scaffolds and implant surfaces. On this basis, this paper further analyzes unresolved issues such as synergistic effect evaluation of ligustrazine and ferulic acid, coupling mechanism of angiogenesis and osteogenesis, evidence from large animal models for implant osseointegration, in vivo release kinetics, and long-term safety, and proposes key directions that need to be focused on during their translation to clinical osseointegration applications, including quantitative evaluation of synergistic effects, verification of the causal relationship between angiogenesis and osteogenesis coupling, and design of controllable delivery systems.关键词
川芎嗪/阿魏酸/骨质疏松/破骨细胞/骨整合/血管新生/骨组织工程Key words
Ligustrazine/ Ferulic Acid/ Osteoporosis/ Osteoclast/ Osseointegration/ Angiogenesis/ Bone Tissue Engineering引用本文复制引用
艾崇文.川芎活性成分在骨质疏松及骨整合中的应用研究进展[EB/OL].(2026-11-09)[2026-11-10].https://sinoxiv.napstic.cn/article/26468088.学科分类
中医学基金
江西中医药大学 2025 年创新专项基金 基于纳米技术中药活性成分在骨科植入物中的应用研究( XJ-S202549 )