基于ICT机制的Fe2+探针研究进展
Research Progress on Fe2+ Probes Based on ICT
摘要
Fe2+在生物体内承担着各种关键的生理功能，其浓度失衡与多种疾病都密切相关，包括神经退行性疾病、铁代谢异常及药物引起的器官损伤等。荧光探针具有响应快、操作简便、适用于活体成像的特点，现在已经成为用于检测Fe2?的重要工具。本文主要系统阐述了配位型探针、氧化还原型探针、化学切断型探针、PET-ICT协同型探针这四类的响应机制与设计原理。此外，还系统讨论了多机制协同、近红外/双光子成像、可逆探针设计及临床转化等方向。
Abstract
Ferrous ion (Fe2+) plays crucial physiological roles in living organisms, and its dyshomeostasis is closely associated with various diseases, including neurodegenerative disorders, iron metabolism abnormalities, and drug-induced organ damage. Fluorescent probes feature rapid response, simple operation, and suitability for in vivo imaging, and have now become important tools for Fe2+ detection. This review systematically elucidates the response mechanisms and design principles of four types of probes: coordination-type, redox-type, chemodosimeter-type, and PET-ICT synergistic probes. Furthermore, future directions such as multi-mechanism synergy, near-infrared/two-photon imaging, reversible probe design, and clinical translation are systematically discussed.关键词
亚铁离子/荧光探针/分子内电荷转移/反应机制/PET-ICT协同Key words
Ferrous ion/Fluorescent probe/Intramolecular charge transfer/Synergistic mechanism/PET-ICT synergy引用本文复制引用
付成琳,卢超群,梁笑.基于ICT机制的Fe2+探针研究进展[EB/OL].(2026-11-12)[2026-11-13].http://www.paper.edu.cn/releasepaper/content/202611-5.学科分类
药学
