确定性横向迁移装置中细胞运动特性的分子动力学研究

eterministic Lateral Displacement(DLD)is a common particle separation technique in which the particles are separated according to their size and the characteristics of microfluidic laminar flow.The traditional DLD theory only considers rigid particles and it is difficult to describe the separation process of flexible particles such as cells.In this paper,the separation,deformation and stress of flexible cell in DLD device were studied by using coarser particle molecular dynamics model and Reynolds similarity principle.The simulation results show that the separation route of DLD cells at nano scale is consistent with the general separation principle at macro-scale.However,in the microscopic scale,the deformation and destruction of cells in the process of cell separation mainly occurred at the contact point between cells and microcolumn,where the maximum stress was exerted.The results reveal the motion details of the flexible particles passing through the DLD device.