抗血管紧张素Ⅱ 1型受体自身抗体在原发性肾小球疾病患者血清中的表达及意义

Objective：To investigate the expression and clinical significance of serum angiotensin Ⅱ type 1 receptor activating antibodies (AT1-AA) in patients with primary glomerular disease.　　Methods：Clinical and pathologic data were collected in patients with primary glomerular disease (n=326).AT1-AA was detected in serum samples by enzyme-linked immunosorbent assay (ELISA).　　Results：①The positive rates of AT1-AA in patients with primary glomerular disease were 35.58%,much higher than those of healthy donors(9.64%)(P<0.01).②Immunosuppressants can inhibit the production of AT1-AA. ③In patients with primary glomerular disease, there were no significant differences between those who had hypertension and those who hadn't hypertension (P>0.05). But they all had significantly higher level of positive incidences than those of healthy donors.④Compared with AT1-AA-negative patients,the AT1-AA-positive patients had significantly higher level of serum globulin and the rate of femal (P<0.05).　　Conclusion：There is high expression of AT1-AA in patients with primary glomerular disease. The instance of primary glomerular disease may be related with autoantibodies against AT1-receptor, which may be relerant with the level of serum globulin and the rate of female patients. There are no relevance between non-malignant hypertension and AT1-AA. Immunosuppressants can effect the expression of AT1-AA.