3D 打印的骨仿生支架的制备及其性能的研究

Organic and inorganic materials with similar composition to bone tissue, such as gelatin methacrylate (GelMA), hydroxyapatite (HAP), and hyaluronic acid (HA), are widely used in bone tissue engineering. In this study, two different bone biomimetic scaffolds (S-GMH and S-GMHH) were fabricated using 3D printing technology based on the above materials. The results of in vitro physicochemical experiments showed that the S-GMH and S-GMHH scaffolds have the characteristics of connected pores and pores, good thermal stability and rheological properties, suitable compressive modulus (0.77 MPa-1.26 MPa) that can promote osteogenic differentiation, and excellent resilience performance. The results of cell experiments showed that S-GMH and S-GMHH scaffolds had good biocompatibility. In addition, the S-GMHH scaffold was able to significantly promote osteogenic differentiation. This study provides twoPreparation and properties of 3Dprinted bone biomimetic scaffolds types of 3D printed biomimetic bone scaffolds that could be good implants for bone repair.