Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium

作者：Mains Douglas、Burke James R.、Foroud Tatiana M.、Cairns Nigel J.、Carlsson Cynthia M.、Kunkle Brian W.、Bush William S.、Mayeux Richard、Pericak-Vance Margaret A.、Haines Jonathan L.、Schellenberg Gerard D.、Rajabli Farid、Benchek Penelope、Lee Wan-Ping、Haut Jacob、Wheeler Nicholas R.、Zhao Yi、Qu Liming、Quiceno Mary、Quinn Joseph F.、Raj Ashok、Raskind Murray、Ringman John M.、Rodriguear Monica、Sano Mary、Seeley William W.、Smith Amanda G.、Smith Janet P.、Jun Gyungah R.、Lah James J.、Farrell John J.、Levey Allan I.、Albert Marilyn S.、Alvarez Lisa、Arnold Steven E.、Baldwin Clinton T.、Beach Thomas G.、Becker James T.、Beekly Duane、Boeve Bradley F.、Bowen James D.、Brewer James、Carlson Christopher S.、Woon Martin、Wright Clinton B.、Wu Chuang-Kuo、Zhu Xiongwei、Cribbs David H.、Crocco Elizabeth A.、Cruchaga Carlos、Cuccaro Michael L.、Cullum Munro、Darby Eveleen、Davis Barbara、Dickson Dennis W.、Faber Kelley M.、Fairchild Thomas J.、Fernandez-Hernandez Victoria、Galasko Douglas R.、Geschwind Daniel H.、Gilbert John R.、Graff-Radford Neill R.、Green Robert C.、Larson Eric B.、Mash Deborah C.、Mukherjee Shubhabrata、Nguyen Trung、Paydarfar David、Peskind Elaine、Petersen Ronald C.、Pierce Aimee、Poon Wayne W.、Potter Huntington、Miller Bruce L.、Miller Joshua W.、Montine Thomas J.、Kuksa Pavel P.、Mez Jesse B.、Sherva Richard M.、Buxbaum Joseph D.、Hall James、Hardy John、Harrell Lindy E.、Head Elizabeth、Henderson Victor W.、Hernandez Michelle、Huentelman Matthew J.、Hyman Bradley T.、Ibanez Laura、Jarvik Gail P.、Johnson Kim、Karydas Anna M.、Kaye Jeffrey A.、Kim Ronald、Kramer Joel H.、Kukull Walter A.、Stern Robert A.、Stevens Alan B.、Sultzer David、Swerdlow Russell H.、Van Deerlin Vivianna M.、Vance Jeffery M.、Vardarajan Badri N.、Weintraub Sandra、Ory Marcia、Paulson Henry L.、Welsh-Bohmer Kathleen A.、Wilms Henrik、Yu Chang-En、Boxer Adam、Palmer Ellen L.、Hohman Timothy、Farlow Martin R.、Evans Denis A.、Wijsman Ellen M.、Barber Robert C.、Frosch Matthew P.、Wang Li-San、Kamboh M. Ilyas、Carrasquillo Minerva M.、Craft Suzanne、Kushch Nicholas、DeCarli Charles、Li Donghe、McCormick Wayne C.、Gamboa Adriana、Small Scott、Martiniuk Frank、McDonough Stefan、Sonnen Joshua A.、Lerner Alan、Lunetta Kathryn L.、Harari Oscar、Woltjer Randall L.、DeToledo John、Ferris Steven、Sager Mark A.、Chung Jaeyoon、Morris John C.、Tsuang Debby W.、Ghetti Bernardino、Fardo David W.、Keene C. Dirk、Song Yeunjoo E.、Ayres Gayle、Margaret Flanagan E.、Dombroski Beth A.、Fallon Kenneth B.、Bennett David、De Jager Philip L.、Chin Nathaniel A.、Rosen Howard J.、Dick Malcolm、Zhang Xiaoling、Chasse Scott、Kowall Neil W.、Tosto Giuseppe、Grabowski Thomas J.、Albin Roger L.、Jin Lee-Way、Allen Mariet、Valladares Otto、Crane Paul K.、Barnes Lisa L.、Reiman Eric M.、Pathak Omkar、Ertekin-Taner NIl¨1fer、Duara Ranjan、Cao Chuanhai、St George-Hyslop Peter、Schneider Julie A.、Leung Yuk Yee、Palmer Raymond、Goate Alison M.、Honig Lawrence S.、Jayadev Suman、Troncoso Juan C.、Fulton-Howard Brian、McDavid Andrew N.、Grunin Michelle A.、Mesulam Marsel、Katz Mindy J.、Iqbal Taha、Logue Mark、Knebl Janice、Asthana Sanjay、Olichney John M.、Blacker Deborah、Saykin Andrew J.、Vinters Harry V.、Lyketsos Constantine G.、Gearing Marla、Atwood Craig S.、Hynan Linda S.、Naj Adam C.、LaFerla Frank M.、Apostolova Liana G.、Sha Jin、van Eldik Linda J.、Perez Victoria、Bird Thomas D.、Parisi Joseph E.、Martin Eden R R.、Schneider Lon S.、Whitehead Patrice L.、McKee Ann C.、Growdon John H.、Chui Helena C.、Hulette Christine M.、Tanzi Rudolph E.、McCurry Susan M.、Chesselet Marie-Francoise、Leverenz James B.、Miller Carol A.、Rogaeva Ekaterina、Massman Paul、Beecham Gary W.、Lucio da Fonseca Eder、Masurkar Arjun、Williams Benjamin、Hamilton-Nelson Kara L.、Pillai Jagan、Myers Amanda J.、Zhu Congcong、Doody Rachelle S.、Kuzma Amanda B.、Cantwell Laura B.、Yu Lei、Williamson Jennifer、Tilson Jeffrey L.、Hamilton Ronald L.、Spina Salvatore、Kauwe John S.、Barral Sandra、Wilhelmsen Kirk C.、Younkin Steven G.、Lieberman Andrew P.、Wisniewski Thomas、Johnson Leigh、Pavlik Valory、Slifer Susan H.、Huebinger Ryan M.、Reisberg Barry、Strittmatter Stephen M.、Adams Perrie M.、Trojanowski John Q.、Benitez Bruno A.、Monuki Edwin S.、Burns Jeffrey M.、Wingo Thomas S.、Lipton Richard B.、Lopez Oscar L.、Farrer Lindsay A.、Polk Marsha、Aguirre Alyssa、Royall Donald R.、Bazemore Katrina、Rosenberg Roger N.、Vonsattel Jean-Paul、Khaleeq Aisha、Masliah Eliezer、Marson Daniel C.、Abner Erin、Vassar Robert、O?ˉBryant Sid、Hakonarson Hakon、Reisch Joan S.、Bertelson John、Roberson Erik D.、Carney Regina M.、Reitz Christiane

作者单位：Department of Health Behavior and Health Systems, University of North Texas Health Science Center||Department of Health Management and Policy, School of Public Health, University of North Texas Health Science CenterDepartment of Medicine, Duke UniversityDepartment of Medical and Molecular Genetics, Indiana University, IndianapolisDepartment of Pathology and Immunology, Washington UniversityWisconsin Alzheimer?ˉs Disease Research Center||Department of Medicine, University of WisconsinDr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami||The John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Population and Quantitative Health Sciences, Case Western Reserve University||Cleveland Institute for Computational Biology, Case Western Reserve UniversityTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia UniversityDr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami||The John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Population and Quantitative Health Sciences, Case Western Reserve University||Cleveland Institute for Computational Biology, Case Western Reserve UniversityPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami||The John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Population and Quantitative Health Sciences, Case Western Reserve UniversityPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics Perelman School of Medicine, University of PennsylvaniaDepartment of Population and Quantitative Health Sciences, Case Western Reserve University||Cleveland Institute for Computational Biology, Case Western Reserve UniversityPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Internal Medicine and Geriatrics, University of North Texas Health Science Center||Department of Medical Education, TCU/UNTHSC School of MedicineDepartment of Neurology, Oregon Health and Science University||Department of Neurology, Portland Veterans Affairs Medical CenterUSF Health Byrd Alzheimer?ˉs Institute, University of South FloridaDepartment of Psychiatry and Behavioral Sciences, University of Washington School of MedicineDepartment of Neurology, University of California Los AngelesAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicineDepartment of Psychiatry, Mount Sinai School of MedicineDepartment of Neurology, University of California San FranciscoUSF Health Byrd Alzheimer?ˉs Institute, University of South FloridaDepartment of Population and Data Sciences, University of Texas Southwestern Medical CenterDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine||Department of Biostatistics, Boston University School of Public Health||Department of Ophthalmology, Boston University Chobanian & Avedisian School of MedicineDepartment of Neurology, Emory UniversityDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of MedicineDepartment of Neurology, Emory UniversityDepartment of Neurology, Johns Hopkins UniversityDepartment of Pharmacology and Neuroscience, University of North Texas Health Science CenterDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of MedicineCivin Laboratory for Neuropathology, Banner Sun Health Research InstituteDepartments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of MedicineNational Alzheimer?ˉs Coordinating Center, University of WashingtonDepartment of Neurology, Mayo Clinic, RochesterSwedish Medical Center, SeattleDepartment of Neurosciences, University of California San DiegoFred Hutchinson Cancer Research Center, SeattleDepartment of Psychiatry, University of Texas at Austin/Dell Medical SchoolEvelyn F. McKnight Brain Institute, Department of Neurology, Miller School of MedicineDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterDepartment of Pathology, Case Western Reserve UniversityDepartment of Neurology, University of California IrvineDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of MiamiNeuroGenomics and Informatics, Washington University||Department of Psychiatry, Washington UniversityThe John P. Hussman Institute for Human Genomics, University of Miami||Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of MiamiDepartment of Psychiatry, University of Texas Southwestern Medical CenterAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicineDepartment of Population and Data Sciences, University of Texas Southwestern Medical CenterDepartment of Neuroscience, Mayo ClinicDepartment of Medical and Molecular Genetics, Indiana University, IndianapolisOffice of Strategy and Measurement, University of North Texas Health Science CenterDepartment of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of MedicineDepartment of Neurosciences, University of California San DiegoNeurogenetics Program, University of California Los Angeles, Los AngelesThe John P. Hussman Institute for Human Genomics, University of Miami||Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of MiamiDepartment of Neuroscience, Mayo Clinic||Department of Neurology, Mayo ClinicDivision of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women?ˉs Hospital and Harvard Medical SchoolKaiser Permanente Washington Health Research InstituteDepartment of Neurology, Miller School of Medicine, University of MiamiDepartment of Medicine, University of Washington, SeattleDepartment of Neurology, University of Texas Southwestern Medical CenterDepartment of Neurology, Dell Medical School, University of Texas at AustinDepartment of Psychiatry and Behavioral Sciences, University of Washington School of MedicineDepartment of Neurology, Mayo Clinic, RochesterDepartment of Neurology, University of California IrvineInstitute for Memory Impairments and Neurological Disorders, University of California IrvineDepartment of Neurology, University of Colorado School of MedicineWeill Institute for Neurosciences, Memory and Aging Center, University of California San FranciscoDepartment of Pathology and Laboratory Medicine, University of California DavisDepartment of Pathology, Stanford University School of MedicinePenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurology, Boston University Chobanian & Avedisian School of MedicineDepartment of Medicine (Biomedical Genetics),Boston University Chobanian & Avedisian School of MedicineDepartment of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer?ˉs Disease, Icahn School of Medicine at Mount Sinai||Department of Neuroscience, Icahn School of Medicine at Mount Sinai||Department of Psychiatry, Mount Sinai School of MedicineDepartment of Pharmacology and Neuroscience, University of North Texas Health Science CenterUCL Institute of Neurology, University College London||Department of Molecular Neuroscience, UCL Institute of Neurology, University College LondonDepartment of Neurology, University of Alabama at BirminghamDepartment of Pathology and Laboratory Medicine, University of California IrvineDepartment of Epidemiology and Population Health, Stanford University||Department of Neurology and Neurological Sciences, Stanford UniversityDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterNeurogenomics Division, Translational Genomics Research InstituteDepartment of Neurology, Massachusetts General Hospital/Harvard Medical SchoolDepartment of Psychiatry, Washington University School of Medicine||Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of MedicineDepartment of Genome Sciences, University of Washington||Department of Medicine (Medical Genetics), University of WashingtonDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterDepartment of Neurology, University of California San FranciscoDepartment of Neurology, Oregon Health and Science University||Department of Neurology, Portland Veterans Affairs Medical CenterDepartment of Pathology and Laboratory Medicine, University of California IrvineDepartment of Neuropsychology, University of California San FranciscoDepartment of Epidemiology, University of WashingtonDepartment of Neurology, Boston University Chobanian & Avedisian School of MedicineCenter for Applied Health Research, Baylor Scott & White Health||Center for Population Health and Aging, Texas A&M University Health Science Center||College of Medicine, Texas A&M University Health Science CenterDepartment of Psychiatry and Human Behavior, University of California IrvineUniversity of Kansas Alzheimer?ˉs Disease Center, University of Kansas Medical CenterPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami||The John P. Hussman Institute for Human Genomics, University of MiamiTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia UniversityDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of MedicineCenter for Population Health and Aging, Texas AandM University Health Science CenterDepartment of Neurology, University of Michigan||Michigan Alzheimer?ˉs Disease Center, University of MichiganDepartment of Psychiatry and Behavioral Sciences, Duke University||Department of Medicine, Duke UniversityDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterDepartment of Medicine, University of Washington, SeattleDepartment of Neurology, University of California San FranciscoDepartment of Population and Quantitative Health Sciences, Case Western Reserve UniversityVanderbilt Memory and Alzheimer?ˉs Center, Department of Neurology, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical CenterDepartment of Neurology, Indiana University, IndianapolisRush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, ChicagoDepartment of Genome Sciences, University of Washington||Department of Medicine (Medical Genetics), University of Washington||Department of Biostatistics, University of WashingtonDepartment of Pharmacology and Neuroscience, University of North Texas Health Science CenterC.S. Kubik Laboratory for Neuropathology, Massachusetts General HospitalPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, University of Pittsburgh||Department of Human Genetics, University of Pittsburgh||Alzheimer?ˉs Disease Research Center, University of PittsburghDepartment of Neuroscience, Mayo ClinicSection of Gerontology and Geriatric Medicine Research, Wake Forest School of Medicine, Winston-SalemThe John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Neurology, University of California DavisDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of MedicineDepartment of Medicine, University of Washington, SeattleDepartment of Health Behavior and Health Systems, University of North Texas Health Science Center||Department of Health Management and Policy, School of Public Health, University of North Texas Health Science CenterTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University||Department of Neurology, Columbia UniversityDepartment of Medicine - Pulmonary, New York UniversityPfizer Worldwide Research and DevelopmentDepartment of Laboratory Medicine and Pathology, University of WashingtonDepartment of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Biostatistics, Boston University School of Public HealthDepartment of Psychiatry, Washington UniversityDepartment of Pathology, Oregon Health and Science UniversityDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterDepartment of Psychiatry, New York UniversityDepartment of Medicine, University of WisconsinDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of MedicineDepartment of Pathology and Immunology, Washington University||Department of Neurology, Washington University||Department of Psychiatry, Washington University School of Medicine||Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of MedicineVA Puget Sound Health Care System/GRECC||Department of Psychiatry and Behavioral Sciences, University of Washington School of MedicineDepartment of Pathology and Laboratory Medicine, Indiana UniversitySanders-Brown Center on Aging, Department of Biostatistics, College of Public Health, University of KentuckyDepartment of Laboratory Medicine and Pathology, University of WashingtonCleveland Institute for Computational Biology, Case Western Reserve University||Department of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Neurology, Dell Medical School, University of Texas at AustinDepartment of Pathology, Northwestern University Feinberg School of Medicine||Cognitive Neurology and Alzheimer?ˉs Disease Center, Northwestern University Feinberg School of MedicinePenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Pathology, University of Alabama at BirminghamDepartment of Neurological Sciences, Rush University Medical Center||Rush Alzheimer?ˉs Disease Center, Rush University Medical CenterCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical CenterGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin||Department of Medicine, University of WisconsinDepartment of Neurology, University of California San FranciscoInstitute for Memory Impairments and Neurological Disorders, University of California IrvineDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine||Department of Biostatistics, Boston University School of Public HealthDepartment of Genetics, University of North Carolina Chapel HillDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine||Department of Pathology, Boston UniversityTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University||Department of Neurology, Columbia UniversityDepartment of Neurology, University of Washington||Department of Radiology, University of WashingtonDepartment of Neurology, University of Michigan||Geriatric Research, Education and Clinical Center (GRECC)||Michigan Alzheimer?ˉs Disease Center, University of MichiganDepartment of Pathology and Laboratory Medicine, University of California DavisDepartment of Neuroscience, Mayo ClinicPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine, University of Washington, SeattleDepartment of Neurological Sciences, Rush University Medical Center||Department of Behavioral Sciences, Rush University Medical Center||Rush Alzheimer?ˉs Disease Center, Rush University Medical CenterNeurogenomics Division, Translational Genomics Research Institute||Arizona Alzheimer?ˉs Consortium||Banner Alzheimer?ˉs Institute||Department of Psychiatry, University of ArizonaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Neuroscience, Mayo Clinic||Department of Neurology, Mayo ClinicWien Center for Alzheimer?ˉs Disease and Memory Disorders, Mount Sinai Medical CenterUSF Health Byrd Alzheimer?ˉs Institute, University of South FloridaCambridge Institute for Medical Research, University of Cambridge||Faculty of Medicine, Department of Medicine (Neurology), University of TorontoDepartment of Neurological Sciences, Rush University Medical Center||Rush Alzheimer?ˉs Disease Center, Rush University Medical Center||Department of Pathology (Neuropathology), Rush University Medical CenterPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Family and Community Medicine, University of Texas Health Science Center San AntonioDepartment of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer?ˉs Disease, Icahn School of Medicine at Mount SinaiTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia UniversityDepartment of Neurology, University of WashingtonDepartment of Pathology, Johns Hopkins UniversityDepartment of Neuroscience, Ronald M. Loeb Center for Alzheimer?ˉs Disease, Icahn School of Medicine at Mount SinaiFred Hutchinson Cancer Research Center, SeattleDepartment of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Pathology, Northwestern University Feinberg School of Medicine||Cognitive Neurology and Alzheimer?ˉs Disease Center, Northwestern University Feinberg School of MedicineDepartment of Neurology, Albert Einstein College of MedicineDepartment of Biostatistics Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine||National Center for PTSD at Boston VA Healthcare System||Department of Psychiatry, Boston University Chobanian & Avedisian School of MedicineDepartment of Health Behavior and Health Systems, University of North Texas Health Science CenterGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin||Department of Medicine, University of Wisconsin||Wisconsin Alzheimer?ˉs Disease Research CenterCenter for Mind and Brain and Department of Neurology, University of California DavisDepartment of Epidemiology, Harvard School of Public Health||Department of Psychiatry, Massachusetts General Hospital/Harvard Medical SchoolDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis||Department of Radiology and Imaging Sciences, Indiana UniversityDepartment of Pathology and Laboratory Medicine, University of California Los Angeles||Department of Neurology, University of California Los AngelesDepartment of Psychiatry, Johns Hopkins UniversityDepartment of Pathology and Laboratory Medicine, Emory University||Emory Alzheimer?ˉs Disease Center, Emory UniversityGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin||Department of Medicine, University of Wisconsin||Wisconsin Alzheimer?ˉs Disease Research CenterDepartment of Psychiatry, University of Texas Southwestern Medical Center||Department of Neurology, University of Texas Southwestern Medical Center||Department of Neurological Surgery, University of Texas Southwestern Medical CenterDepartment of Biostatistics Perelman School of Medicine, University of Pennsylvania||Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurobiology and Behavior, University of California IrvineDepartments of Neurology Indiana University School of Medicine||Indiana Alzheimer?ˉs Disease Research Center, Indiana University School of MedicineDepartment of Biostatistics Perelman School of Medicine, University of PennsylvaniaSanders-Brown Center on Aging, Department of Neuroscience, College of Medicine, University of KentuckyDepartments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science CenterVA Puget Sound Health Care System/GRECC||Department of Neurology, University of WashingtonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, RochesterThe John P. Hussman Institute for Human Genomics, University of Miami||Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of MiamiDepartment of Psychiatry, University of Southern California||Department of Neurology, University of Southern California, Los AngelesThe John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine||Department of Pathology, Boston University Chobanian & Avedisian School of MedicineDepartment of Neurology, Massachusetts General Hospital/Harvard Medical SchoolDepartment of Neurology, University of Southern California, Los AngelesDepartment of Pathology, Duke UniversityDepartment of Neurology, Massachusetts General Hospital/Harvard Medical SchoolSchool of Nursing Northwest Research Group on Aging, University of WashingtonNeurogenetics Program, University of California Los Angeles, Los AngelesCleveland Clinic Lou Ruvo Center for Brain Health, Cleveland ClinicDepartment of Pathology, University of Southern CaliforniaTanz Centre for Research in Neurodegenerative Disease, University of TorontoAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicineThe John P. Hussman Institute for Human Genomics, University of MiamiThe John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Psychiatry, New York UniversityDepartment of Neurology, Section of Gerontology and Geriatric Medicine Research, Wake Forest School of MedicineThe John P. Hussman Institute for Human Genomics, University of MiamiCleveland Clinic Lou Ruvo Center for Brain Health, Cleveland ClinicDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of MiamiDepartment of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of MedicineAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicinePenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurological Sciences, Rush University Medical Center||Rush Alzheimer?ˉs Disease Center, Rush University Medical CenterTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia UniversityRenaissance Computing Institute, University of North Carolina Chapel HillDepartment of Pathology (Neuropathology), University of PittsburghDepartment of Pathology and Laboratory Medicine, Indiana UniversityDepartment of Neuroscience, Brigham Young University||Department of Biology, Brigham Young UniversityTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University||Gertrude H. Sergievsky Center, Columbia University, New York||Department of Neurology, Columbia UniversityDepartment of Genetics, University of North Carolina Chapel HillDepartment of Neuroscience, Mayo Clinic||Department of Neurology, Mayo ClinicDepartment of Pathology, University of MichiganDepartment of Psychiatry, New York University Grossman School of Medicine||Center for Cognitive Neurology and Departments of Neurology and Pathology, New York University Grossman School of MedicineDepartment of Health Behavior and Health Systems, University of North Texas Health Science CenterAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicineThe John P. Hussman Institute for Human Genomics, University of MiamiDepartment of Surgery, University of Texas Southwestern Medical CenterAlzheimer?ˉs Disease Center, New York University||Department of Psychiatry, New York UniversityProgram in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of MedicineDepartment of Psychiatry, University of Texas Southwestern Medical CenterPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of MedicineDepartment of Pathology and Laboratory Medicine and Alzheimer?ˉs Disease Research Center, University of California IrvineUniversity of Kansas Alzheimer?ˉs Disease Center, University of Kansas Medical CenterDepartment of Neurology, Emory UniversityDepartment of Neurology, Albert Einstein College of MedicineDepartments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of MedicineDepartment of Medicine (Biomedical Genetics),Boston University Chobanian & Avedisian School of Medicine||Department of Neurology, Boston University Chobanian & Avedisian School of Medicine||Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine||Department of Epidemiology, Boston University School of Public Health||Department of Biostatistics, Boston University School of Public HealthDepartment of Family and Community Medicine, University of Texas Health Science Center San AntonioDepartment of Neurology, Dell Medical School, University of Texas at AustinDepartments of Psychiatry, Medicine, Family and Community Medicine, and the Glenn Biggs Institute for Alzheimer?ˉs and Neurodegenerative Diseases, UT Health Science Center at San AntonioDepartment of Biostatistics Perelman School of Medicine, University of PennsylvaniaDepartment of Neurology, University of Texas Southwestern Medical CenterTaub Institute for Research in Alzheimer?ˉs Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia UniversityAlzheimer?ˉs Disease and Memory Disorders Center, Baylor College of MedicineDepartment of Neurosciences, University of California San Diego||Department of Pathology, University of California San DiegoDepartment of Neurology, University of Alabama at BirminghamSanders-Brown Center on Aging, Department of Epidemiology, College of Public Health, University of KentuckyDepartment of Pathology, Northwestern University Feinberg School of Medicine||Cognitive Neurology and Alzheimer?ˉs Disease Center, Northwestern University Feinberg School of MedicineInstitute for Translational Research, University of North Texas Health Science CenterCenter for Applied Genomics, Children?ˉs Hospital of Philadelphia||Division of Human Genetics, Department of Pediatrics, Perelman School of Medicine, University of PennsylvaniaDepartment of Population and Data Sciences, University of Texas Southwestern Medical CenterDepartment of Psychiatry, University of Texas at Austin/Dell Medical SchoolDepartment of Neurology, University of Alabama at BirminghamMental Health and Behavioral Science Service, Bruce W. Carter VA Medical CenterDepartment of Epidemiology, Columbia University||Gertrude H. Sergievsky Center, Columbia University, New York||Department of Neurology, Columbia University

DOI：10.1101/2023.07.06.23292311

学科分类：神经病学、精神病学医学研究方法基础医学

英文关键词：Genome-wide association study (GWAS)GWAS Meta-AnalysisAlzheimer Diseasemulti-ancestryancestry-specific

推荐引用：Mains Douglas,Burke James R.,Foroud Tatiana M.,Cairns Nigel J.,Carlsson Cynthia M.,Kunkle Brian W.,Bush William S.,Mayeux Richard,Pericak-Vance Margaret A.,Haines Jonathan L.,Schellenberg Gerard D.,Rajabli Farid,Benchek Penelope,Lee Wan-Ping,Haut Jacob,Wheeler Nicholas R.,Zhao Yi,Qu Liming,Quiceno Mary,Quinn Joseph F.,Raj Ashok,Raskind Murray,Ringman John M.,Rodriguear Monica,Sano Mary,Seeley William W.,Smith Amanda G.,Smith Janet P.,Jun Gyungah R.,Lah James J.,Farrell John J.,Levey Allan I.,Albert Marilyn S.,Alvarez Lisa,Arnold Steven E.,Baldwin Clinton T.,Beach Thomas G.,Becker James T.,Beekly Duane,Boeve Bradley F.,Bowen James D.,Brewer James,Carlson Christopher S.,Woon Martin,Wright Clinton B.,Wu Chuang-Kuo,Zhu Xiongwei,Cribbs David H.,Crocco Elizabeth A.,Cruchaga Carlos,Cuccaro Michael L.,Cullum Munro,Darby Eveleen,Davis Barbara,Dickson Dennis W.,Faber Kelley M.,Fairchild Thomas J.,Fernandez-Hernandez Victoria,Galasko Douglas R.,Geschwind Daniel H.,Gilbert John R.,Graff-Radford Neill R.,Green Robert C.,Larson Eric B.,Mash Deborah C.,Mukherjee Shubhabrata,Nguyen Trung,Paydarfar David,Peskind Elaine,Petersen Ronald C.,Pierce Aimee,Poon Wayne W.,Potter Huntington,Miller Bruce L.,Miller Joshua W.,Montine Thomas J.,Kuksa Pavel P.,Mez Jesse B.,Sherva Richard M.,Buxbaum Joseph D.,Hall James,Hardy John,Harrell Lindy E.,Head Elizabeth,Henderson Victor W.,Hernandez Michelle,Huentelman Matthew J.,Hyman Bradley T.,Ibanez Laura,Jarvik Gail P.,Johnson Kim,Karydas Anna M.,Kaye Jeffrey A.,Kim Ronald,Kramer Joel H.,Kukull Walter A.,Stern Robert A.,Stevens Alan B.,Sultzer David,Swerdlow Russell H.,Van Deerlin Vivianna M.,Vance Jeffery M.,Vardarajan Badri N.,Weintraub Sandra,Ory Marcia,Paulson Henry L.,Welsh-Bohmer Kathleen A.,Wilms Henrik,Yu Chang-En,Boxer Adam,Palmer Ellen L.,Hohman Timothy,Farlow Martin R.,Evans Denis A.,Wijsman Ellen M.,Barber Robert C.,Frosch Matthew P.,Wang Li-San,Kamboh M. Ilyas,Carrasquillo Minerva M.,Craft Suzanne,Kushch Nicholas,DeCarli Charles,Li Donghe,McCormick Wayne C.,Gamboa Adriana,Small Scott,Martiniuk Frank,McDonough Stefan,Sonnen Joshua A.,Lerner Alan,Lunetta Kathryn L.,Harari Oscar,Woltjer Randall L.,DeToledo John,Ferris Steven,Sager Mark A.,Chung Jaeyoon,Morris John C.,Tsuang Debby W.,Ghetti Bernardino,Fardo David W.,Keene C. Dirk,Song Yeunjoo E.,Ayres Gayle,Margaret Flanagan E.,Dombroski Beth A.,Fallon Kenneth B.,Bennett David,De Jager Philip L.,Chin Nathaniel A.,Rosen Howard J.,Dick Malcolm,Zhang Xiaoling,Chasse Scott,Kowall Neil W.,Tosto Giuseppe,Grabowski Thomas J.,Albin Roger L.,Jin Lee-Way,Allen Mariet,Valladares Otto,Crane Paul K.,Barnes Lisa L.,Reiman Eric M.,Pathak Omkar,Ertekin-Taner NIl¨1fer,Duara Ranjan,Cao Chuanhai,St George-Hyslop Peter,Schneider Julie A.,Leung Yuk Yee,Palmer Raymond,Goate Alison M.,Honig Lawrence S.,Jayadev Suman,Troncoso Juan C.,Fulton-Howard Brian,McDavid Andrew N.,Grunin Michelle A.,Mesulam Marsel,Katz Mindy J.,Iqbal Taha,Logue Mark,Knebl Janice,Asthana Sanjay,Olichney John M.,Blacker Deborah,Saykin Andrew J.,Vinters Harry V.,Lyketsos Constantine G.,Gearing Marla,Atwood Craig S.,Hynan Linda S.,Naj Adam C.,LaFerla Frank M.,Apostolova Liana G.,Sha Jin,van Eldik Linda J.,Perez Victoria,Bird Thomas D.,Parisi Joseph E.,Martin Eden R R.,Schneider Lon S.,Whitehead Patrice L.,McKee Ann C.,Growdon John H.,Chui Helena C.,Hulette Christine M.,Tanzi Rudolph E.,McCurry Susan M.,Chesselet Marie-Francoise,Leverenz James B.,Miller Carol A.,Rogaeva Ekaterina,Massman Paul,Beecham Gary W.,Lucio da Fonseca Eder,Masurkar Arjun,Williams Benjamin,Hamilton-Nelson Kara L.,Pillai Jagan,Myers Amanda J.,Zhu Congcong,Doody Rachelle S.,Kuzma Amanda B.,Cantwell Laura B.,Yu Lei,Williamson Jennifer,Tilson Jeffrey L.,Hamilton Ronald L.,Spina Salvatore,Kauwe John S.,Barral Sandra,Wilhelmsen Kirk C.,Younkin Steven G.,Lieberman Andrew P.,Wisniewski Thomas,Johnson Leigh,Pavlik Valory,Slifer Susan H.,Huebinger Ryan M.,Reisberg Barry,Strittmatter Stephen M.,Adams Perrie M.,Trojanowski John Q.,Benitez Bruno A.,Monuki Edwin S.,Burns Jeffrey M.,Wingo Thomas S.,Lipton Richard B.,Lopez Oscar L.,Farrer Lindsay A.,Polk Marsha,Aguirre Alyssa,Royall Donald R.,Bazemore Katrina,Rosenberg Roger N.,Vonsattel Jean-Paul,Khaleeq Aisha,Masliah Eliezer,Marson Daniel C.,Abner Erin,Vassar Robert,O?ˉBryant Sid,Hakonarson Hakon,Reisch Joan S.,Bertelson John,Roberson Erik D.,Carney Regina M.,Reitz Christiane.Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium[EB/OL].(2025-03-28)[2025-06-12].https://www.medrxiv.org/content/10.1101/2023.07.06.23292311.点此复制