Association between proteomic blood biomarkers and DTI/NODDI metrics in adolescent football players
Association between proteomic blood biomarkers and DTI/NODDI metrics in adolescent football players
ABSTRACT The objective of the study was to examine the association between diffusion MRI techniques [diffusion tensor imaging (DTI) and neurite orientation/dispersion density imaging (NODDI)] and brain-injury blood biomarker levels [Tau, neurofilament-light (NfL), glial-fibrillary-acidic-protein (GFAP)] in high-school football and cross-country runners at their baseline, aiming to detect cumulative neuronal damage from prior seasons. Twenty-five football players and 8 cross-country runners underwent MRI and blood biomarker measures during preseason data collection. The whole-brain, tract-based spatial statistics was conducted for six diffusion metrics: fractional anisotropy (FA), mean diffusivity (MD), axial/radial diffusivity (AD, RD), neurite density index (NDI), and orientation dispersion index (ODI). Diffusion metrics and blood biomarker levels were compared between groups and associated within each group. The football group showed lower AD and MD than the cross-country group in various axonal tracts of the right hemisphere. Elevated ODI was observed in the football group in the right hemisphere of the corticospinal tract. Blood biomarker levels were consistent between groups except for elevated Tau levels in the cross-country group. Tau level was positively associated with MD and negatively associated with NDI in the corpus callosum of football players, but not in cross-country runners. Our data suggest that football players may develop axonal microstructural abnormality. Levels of MD and NDI in the corpus callosum were associated with serum Tau levels, highlighting the vulnerability of the corpus callosum against cumulative head impacts. Despite observing multimodal associations in some brain areas, neuroimaging and blood biomarkers may not strongly correlate to reflect the severity of brain damage.
Shin Andrea、Ejima Keisuke、Steinfeldt Jesse A.、Nowak Madeleine K.、Newman Sharlene D.、Huibregtse Megan E.、Macy Jonathan T.、Chen Zhongxue、Cheng Hu、Kercher Kyle、Kawata Keisuke
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of MedicineDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana UniversityDepartment of Counseling and Educational Psychology, School of Education, Indiana UniversityDepartment of Kinesiology, School of Public Health-Bloomington, Indiana UniversityProgram in Neuroscience, College of Arts and Sciences, Indiana University||Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana University||Alabama Life Research Institute, University of AlabamaDepartment of Kinesiology, School of Public Health-Bloomington, Indiana UniversityDepartment of Applied Health Science, School of Public Health-Bloomington, Indiana UniversityDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana UniversityProgram in Neuroscience, College of Arts and Sciences, Indiana University||Department of Psychological and Brain Sciences, College of Arts and Sciences, Indiana UniversityDepartment of Applied Health Science, School of Public Health-Bloomington, Indiana UniversityDepartment of Kinesiology, School of Public Health-Bloomington, Indiana University||Program in Neuroscience, College of Arts and Sciences, Indiana University
医学研究方法神经病学、精神病学生物科学研究方法、生物科学研究技术
subconcussionbrain injurydiffusion tensor imagingneurite orientation dispersion and density imagingblood biomarkerfootballyouthconcussion
Shin Andrea,Ejima Keisuke,Steinfeldt Jesse A.,Nowak Madeleine K.,Newman Sharlene D.,Huibregtse Megan E.,Macy Jonathan T.,Chen Zhongxue,Cheng Hu,Kercher Kyle,Kawata Keisuke.Association between proteomic blood biomarkers and DTI/NODDI metrics in adolescent football players[EB/OL].(2025-03-28)[2025-08-11].https://www.biorxiv.org/content/10.1101/2020.02.20.958694.点此复制
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