骨肉瘤凋亡与耐药相关机制研究进展

Osteosarcoma is one of the most common malignant bone tumors. The neoadjuvant chemotherapy is an important therapeutic method for osteosarcoma. Abnormal apoptosis and drug resistance are major causes of treat failure. These two malignant biological behaviors may involve changes of various gene and protein pathways. Study of these molecular pathways may help to reveal the mechanism of abnormal apoptosis and drug resistance on osteosarcoma, which is expected to improve the clinical curative effect of this malignant tumor.