The cross-sectional area of the vagus nerve is not reduced in Parkinson’s Disease patients
The cross-sectional area of the vagus nerve is not reduced in Parkinson’s Disease patients
Abstract ObjectiveRecent studies have revealed the importance of the gut brain axis in the development of Parkinson’s disease (PD). It has also been suggested that the cross-sectional area (CSA) of the vagus nerve can be used in the diagnosis of PD. Here, we hypothesize that the CSA of the vagus nerve is decreased in PD patients compared to control subjects. MethodsIn this study we measured the CSA of the vagus nerve on both sides in 31 patients with PD and 51 healthy controls at the level of the common carotid artery using high-resolution ultrasound. ResultsThe CSA of the vagus nerve was not reduced in PD patients compared to controls (p = 0.391. The mean CSA of the left vagus nerve was significantly smaller than the right (p < 0.001). There was no significant correlation between age, gender and autonomic symptoms with the CSA of the left (p = 0.128) and right vagus nerve (p = 0.166). ConclusionThese findings show that the CSA of the vagus nerve using ultrasonography is not a reliable diagnostic tool in the diagnosis of PD. HighlightsThe cross-sectional area of the vagus nerve is not decreased in Parkinson disease patients.The cross-sectional area of the vagus nerve does not correlate with autonomic symptoms.Measurement of the vagus nerve cross-sectional area has a high inter-observer correlation.
Oosterloo Mayke、Mess Werner H.、Sijben Laura C.J.、Kuijf Mark、Walter Uwe、Weber Wim M.、Janssen Marcus L.F.、Janssen A. Miranda L.
School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University||Department of Neurology, Maastricht University Medical CenterDepartment of Clinical Neurophysiology, Maastricht University Medical Center||School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht UniversityDepartment of Clinical Neurophysiology, Maastricht University Medical Center||School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht UniversitySchool for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University||Department of Neurology, Maastricht University Medical CenterDepartment of Neurology, University of Rostock||German Centre for Neurodegenerative Diseases (DZNE)School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University||Department of Neurology, Maastricht University Medical CenterDepartment of Clinical Neurophysiology, Maastricht University Medical Center||School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University||Department of Neurology, Maastricht University Medical CenterDepartment of Methodology and Statistics, School for Public Health and Primary Care, Maastricht University
神经病学、精神病学基础医学医学研究方法
Parkinson’s Diseasevagus nerveultrasonographycross-sectional areaautonomic symptoms
Oosterloo Mayke,Mess Werner H.,Sijben Laura C.J.,Kuijf Mark,Walter Uwe,Weber Wim M.,Janssen Marcus L.F.,Janssen A. Miranda L..The cross-sectional area of the vagus nerve is not reduced in Parkinson’s Disease patients[EB/OL].(2025-03-28)[2025-04-29].https://www.medrxiv.org/content/10.1101/2020.10.19.20214973.点此复制
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