骨桥蛋白在免疫调控中的功能研究进展

Osteopontin (OPN) is a phosphorylated glycoprotein containing the RGD （Arg-Gly-Asp）integrin binding site. Until now, researchers found that OPN plays an important role in the cell development, proliferation, migration, and tumor growth and metastasis as a cytokine-like secreted molecule. Pleaty of work also demomstrated that secreted OPN is an important regulatory molecule in immune response. Recent studies demonstrated that there is an intracellular form of OPN (iOPN), which also plays an important role in varieties of life activities including immune regulation. This review mainly outlines the fast developing knowledge on OPN in the regulation of immune responses.