Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
ABSTRACT Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, SARS-CoV-2 immunity has been studied extensively in blood. However, the capacity of peripheral vaccination to generate sustained humoral and cellular immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Bronchoalveolar lavage samples obtained from vaccinated donors with or without prior infection revealed enrichment of spike-specific antibodies, class-switched memory B cells and T cells in the lung mucosa compared to the periphery in the setting of hybrid immunity, whereas in the context of vaccination alone, local anti-viral immunity was limited to antibody responses. Spike-specific T cells persisted in the lung mucosa for up to 5 months post-vaccination and multi-specific T cell responses were detected at least up to 11 months post-infection. Thus, durable lung mucosal immunity against SARS-CoV-2 seen after hybrid exposure cannot be achieved by peripheral vaccination alone, supporting the need for vaccines targeting the airways.
Robinson Ryan、Hyder-Wright Angela、Liatsikos Konstantinos、Hamilton Josh、Solorzano Carla、Lambe Teresa、Draper Simon J.、Diniz Mariana O.、Ferreira Daniela M.、Urban Britta C.、Mitsi Elena、Onyema Onyia、Weiskopf Daniela、Farrar Madlen、Maini Mala K.、Rein¨| Jes¨2s、Sette Alessandro、Collins Andrea M.
Department of Clinical Science, Liverpool School of Tropical MedicineDepartment of Clinical Science, Liverpool School of Tropical MedicineDepartment of Clinical Science, Liverpool School of Tropical MedicineDepartment of Clinical Science, Liverpool School of Tropical MedicineOxford Vaccine Group, Department of Paediatrics, University of Oxford||Department of Clinical Science, Liverpool School of Tropical MedicineOxford Vaccine Group, Department of Paediatrics, University of Oxford||Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of OxfordDepartment of Biochemistry, University of OxfordDivision of Infection and Immunity and Institute of Immunity and TransplantationOxford Vaccine Group, Department of Paediatrics, University of Oxford||Department of Clinical Science, Liverpool School of Tropical MedicineOxford Vaccine Group, Department of Paediatrics, University of Oxford||Department of Clinical Science, Liverpool School of Tropical MedicineOxford Vaccine Group, Department of Paediatrics, University of Oxford||Department of Clinical Science, Liverpool School of Tropical MedicineDepartment of Clinical Science, Liverpool School of Tropical MedicineCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Department of Clinical Science, Liverpool School of Tropical MedicineDivision of Infection and Immunity and Institute of Immunity and TransplantationOxford Vaccine Group, Department of Paediatrics, University of Oxford||Department of Clinical Science, Liverpool School of Tropical MedicineCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaDepartment of Clinical Science, Liverpool School of Tropical Medicine
医药卫生理论医学研究方法预防医学
human lung mucosahybrid immunitySARS-CoV-2 vaccinationairway memory T cells
Robinson Ryan,Hyder-Wright Angela,Liatsikos Konstantinos,Hamilton Josh,Solorzano Carla,Lambe Teresa,Draper Simon J.,Diniz Mariana O.,Ferreira Daniela M.,Urban Britta C.,Mitsi Elena,Onyema Onyia,Weiskopf Daniela,Farrar Madlen,Maini Mala K.,Rein¨| Jes¨2s,Sette Alessandro,Collins Andrea M..Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination[EB/OL].(2025-03-28)[2025-07-02].https://www.biorxiv.org/content/10.1101/2023.01.25.525485.点此复制
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