基于TSE-SERS技术的酒精饮料中甲醇的快速检测

eveloped a thermal purging separation and enrichment device (TSE) that can use the difference in boiling point of the target substance and the substrate to realize the separation and enrichment of the two, as a pre-processing device for surface enhanced Raman spectroscopy (SERS) detection; at the same time, the parameters were carried out. The optimization and miniaturization of the device realize efficient detection under high recovery rate. In the quantitative analysis of methanol, a small molecule substance in alcoholic beverages, the thermal purge separation and enrichment device coupled with catalytic strategy solves the problem of small Raman scattering cross-section of methanol and difficulty in adopting derivatization strategies, resulting in barriers to SERS detection. Methanol is converted to formaldehyde, which can be derivatized. In order to avoid the interference of acetaldehyde after a large amount of ethanol is catalyzed, acetylacetone derivatization that does not interact with acetaldehyde is used in the detection of high-concentration wine. Through this method, the detection of formaldehyde in methanol standard solution is achieved in the linear range of 0.001~0.2 μg/mL and 0.5~100 μg/mL, with a detection limit of 0.001 μg/mL; for the detection of methanol in wine, sake and high-grade liquor, The detection limit can be as low as 0.1μg/mL, showing a wide linear range, and the detection time can be controlled within 20 min.)