脊髓胶质细胞在神经病理性痛作用机制的研究进展

his study was aim to investigate the mechanisms underlying the modulation effect of spinal glial cells in neuropathic pain. In recent years, the studies showing that spinal cord microglia and astrocytes are activated in neuropathic pain .Then the TLR4, IL-1β, nNOS, MMP2, MMP9, CGRP, and fractalkine are increased, and the ERK1/2 signaling pathways are activated in neuropathic pain. In addition, the studies have shown that activated microglia are involved in the formation of pain during early stages of neuropathic pain and that astrocytes are involved in the modulation of neuropathic pain maintenance. Inhibition of spinal glial activity will decrease the expression of inflammatory cytokines, indicating that glial cells involved in the pathogenesis of pathological pain. Its mechanism inhibits neuronal excitability by inhibiting glial cell and neuronal - glial cell viability.The inhibition of glial activation which will not release inflammatory cytokines, neurotransmitters, cell nutrition factors and other substances, while inhibiting the ERK1 / 2 signaling pathway, inhibit the transduction of pain information and thus alleviate neuropathic pain.