MicroRNA124参与肺动脉高压调控的研究进展

Pulmonary arterial hypertension (PAH) is a common disease caused by multiple factors, known as "cardiovascular cancer", characterized by high mortality and poor prognosis. MicroRNAs (miRNAs) are a class of highly conserved, evolutionarily single-stranded non-coding small RNA with a length of about 19~25 nucleotides. They can directly degrade the mRNA or inhibit the translation of the target mRNA by binding to the 3\' untranslated region (3\'-UTR) of the target mRNA. In recent years, more and more evidence has shown that miRNAs play a regulatory role in PAH patients and in PAH experimental animal models, and their abnormal expression can cause phenotypic changes in PAH vascular cells, leading to vascular remodeling. The decrease of microRNA-124(miR-124) plays an important role in regulating the activation phenotype of pulmonary vascular cells, and up-regulation of miR-124 level can reverse the continuous activation phenotype of PAH vascular cells. This paper mainly reviewsthe progress of miR-124 in controlling PAH.