卡介菌多糖核酸（BCG-PSN）对小鼠的一般毒性和致突变研究

o investigate the toxicological effect of Bacillus Calmette-Guerin -polysaccharide-nucleic acid （BCG-PSN） on animals, the acute toxicity, inferior-chromice toxicity, mutagenic actions of BCG-PSN to ICR mice were studied in this paper. The results revealed that the LD50 of BCG-PSN in mice is higher than 2000 mgokg-1obw-1 which is the maximum dissolubility of BCG-PSN, showing that there is no acute toxicity to mice. The inferior-chronic toxicity of high dose group（1000 mgokg-1obw-1）in mice revealed that BCG-PSN result in the toxic responses characterized by chilly, move reduction, the fur fluffiness, diarrhea and more eye secretion within 48 h after BCG-PSN injection. The slight anemia and weak kidney injure can be induced with high dosage and long time exposure to BCG-PSN injection, however there were no toxic responses with middle and low dose after long time exposure to BCG-PSN. The negative results of the cellular medullares micronucleus test and the teratospermia test demonstrated that BCG-PSN has low mutagenic action.