基于络病理论探讨VEGF、MVD、LVD与子宫内膜癌的相关性
he research of detecting the tissue level of VEGF,MVD,LVD of endometrial carcinoma basis on
目的：通过测定47例子宫内膜非典型增生及子宫内膜癌病理组织的血管内皮生长因子（VEGF）、微血管密度（MVD，以CD105标记）和微淋巴管密度（LVD，以D2-40标记），探讨其在子宫内膜非典型增生及子宫内膜癌中的表达规律及与各种证型的关系，初步探讨基于络病理论子宫内膜癌病机的实验基础。方法：免疫组化法测定VEGF、MVD、LVD。结果：VEGF、MVD、LVD在子宫内膜癌中表达高于子宫内膜非典型增生组织中，不同证型中表达亦不同。其中，湿毒瘀结证中三者测定值均为最高。VEGF在血热证中表达最低，其次分别为气虚证、血瘀证。MVD及LVD的表达以气虚证最低；前者血热证高于血瘀证，后者血瘀证高于血热证。结论：在子宫内膜癌病例中，VEGF、MVD、LVD的表达高于子宫内膜非典型增生的病例，提示子宫内膜癌的血管生成及淋巴管生成比子宫内膜非典型增生显著，具有统计学意义。从三者与中医证型的关系分析，发现不同证型对新生血管占优势还是新生淋巴管占优势不同，提示在临床治疗中应根据辨证选用通络的方法。
In this paper，a research was hold in 47cases of endometrial atypical hyperplasia and EC diagnosed by pathology.After detecting the tissue level of VEGF、MVD、LVD，we evaluate and analyze their expression in pathological tissue to find their relativity with TCM syndromes.The expression value and positive proportion of VEGF、MVD and LVD in EC are higher than those in endometrial atypical hyperplasia,with statistical significance.In this research ,the highest value of VEGF、MVD and LVD can be seen in "accumulation of damp toxins"syndrome."Blood-heat"has the lowest VEGF level,followed by "qi deficiency"and"blood stasis".The expression level of MVD and LVD lines the lowest in "qi deficiency",and highest in "accumulation of damp toxins".The level of MVD is much higher in "Blood-heat"than "blood stasis";but LVD is on the cantrary."Dredging collaterals"could be an effective method in clinical therapy according to TCM syndrome differentiation.
杨巧慧、薛晓鸥
中医学妇产科学肿瘤学
子宫内膜癌络病理论VEGFLVDMVD
ECPathogenesis TCM collateral disease theoryVEGFMVDLVD
杨巧慧,薛晓鸥.基于络病理论探讨VEGF、MVD、LVD与子宫内膜癌的相关性[EB/OL].(2014-01-27)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201401-1213.点此复制
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