Long COVID In Adults at 12 Months After Mild-to-Moderate SARS-CoV-2 Infection
Long COVID In Adults at 12 Months After Mild-to-Moderate SARS-CoV-2 Infection
Abstract BackgroundIn a proportion of patients recovered from the acute COVID-19 phase, a variable range of symptoms has been observed to persist for at least 6-months. ObjectivesThe main aim of this study was to evaluate the prevalence of COVID-related symptoms 12-months after the onset of mild-to-moderate disease. MethodsProspective study based on structured questionnaires and additional outcomes. Results304/354 patients completing the survey at baseline also completed the follow-up interview (85.9%; median [range] age, 47 [18-76] years; 185 [60.9%] women). Persistence of at least one symptom at 12-months follow-up was reported by 161 patients (53.0%). The most commonly reported symptom of long COVID was felt tired (n=83, 27.3%), followed by smell or taste impairment (n=67, 22.0%), shortness of breath (n=39, 12.8%) and muscle pain (n=28, 9.2%). Being females (OR=1.64; 95% CI: 1.00-2.70), aged between 40-54 (OR=1.92; 95% CI: 1.07-3.44), having a BMI ≥25 (OR=1.67; 95% CI: 1.00-2.78), and experiencing more symptoms during the acute phase of the disease (OR=8.71 for ≥8 symptoms; 95% CI: 2.73-27.76) were associated with long COVID. Persistence of symptoms showed a significant impact on quality of life (p<0.0001) and depression scale scores (p=0.0102). ConclusionMore than half of patients with previous mild-to-moderate symptomatic COVID-19 complained the persistence of at least one symptom 12-months after the onset of the illness.
Tirelli Giancarlo、Boscolo-Rizzo Paolo、Polesel Jerry、D?ˉAlessandro Andrea、Borsetto Daniele、Zanelli Enrico、Lazzarin Chiara、Guida Francesco、Pengo Martino、Tofanelli Margherita、Marzolino Riccardo、Gardenal Nicoletta、Antonucci Paolo、Sacchet Erica、Marcuzzo Alberto Vito、Capriotti Vincenzo
Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCSDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of ENT, Addenbrooke?ˉs Hospital, Cambridge University Hospitals NHS Foundation TrustDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano IRCCS, Ospedale San LucaDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of TriesteDepartment of Neurosciences, Section of Otolaryngology, Papa Giovanni XXIII General Hospital
医学研究方法临床医学内科学
COVID-19chronic COVID syndromelong COVIDlong haulersSARS-CoV-2
Tirelli Giancarlo,Boscolo-Rizzo Paolo,Polesel Jerry,D?ˉAlessandro Andrea,Borsetto Daniele,Zanelli Enrico,Lazzarin Chiara,Guida Francesco,Pengo Martino,Tofanelli Margherita,Marzolino Riccardo,Gardenal Nicoletta,Antonucci Paolo,Sacchet Erica,Marcuzzo Alberto Vito,Capriotti Vincenzo.Long COVID In Adults at 12 Months After Mild-to-Moderate SARS-CoV-2 Infection[EB/OL].(2025-03-28)[2025-07-16].https://www.medrxiv.org/content/10.1101/2021.04.12.21255343.点此复制
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