P-gp抑制剂与吸收促进剂对蓬子菜中活性成分肠吸收的影响
Effect of P-gp inhibitor and absorption enhancers on intestinal absorption of active ingredient from Galium verum L.
目的：考察P-gp抑制剂与吸收促进剂对蓬子菜中活性成分肠吸收的促进作用。方法：采用大鼠肠襻模型及HPLC测定方法，以活性成分DXG的剩余百分数(R%)和肠吸收转化率(A%)为评价指标，考察P-gp抑制剂与吸收促进剂对蓬子菜中活性成分肠吸收的影响。结果:与对照组相比，各组DXG剩余百分数减少，单位时间吸收转化率增加，有效改善蓬子菜中活性成分的肠吸收。结论:P-gp抑制剂与吸收促进剂对蓬子菜中活性成分的肠吸收具有促进作用，可提高蓬子菜活性成分的生物利用度，为蓬子菜的新药研究提供新的依据。
Objective: To study the effect of P-gp inhibitor and absorption enhancers on intestinal absorption of active ingredient from Galium verum L. Methods: The intestinal loop model and HPLC were used. Percentage of residual and conversion rate of absorption were evaluation parameter. Results: Compared with the control group, percentage of residual is decreasing and conversion rate of absorption is increasing respectively. Absorption of active ingredient from Galium verum L. was improved well. Conclusion: P-gp inhibitor and absorption enhancers could increase intestinal absorption and improve the bioavailability of active ingredient from Galium verum L., which can provide the basis for research of Galium verum L.
孔晓悦、张凯、王洪梅、李聪慧、马英丽、崔明宇
药学基础医学
蓬子菜XGP-gp抑制剂吸收促进剂肠吸收
Galium verum L.DXGP-gp inhibitorabsorption enhancersintestinal absorption
孔晓悦,张凯,王洪梅,李聪慧,马英丽,崔明宇.P-gp抑制剂与吸收促进剂对蓬子菜中活性成分肠吸收的影响[EB/OL].(2016-09-30)[2025-07-22].http://www.paper.edu.cn/releasepaper/content/201609-289.点此复制
评论