Generation of medical isotopes 47-Sc, 67-Cu through laser-induced (γ, p) reaction

Short-lived medical isotopes and their generators are typically produced in nuclear reactors and cyclotrons that require extensive facilities. However, considering the environmental concerns and economic costs of these traditional approaches, modern laser technology, which provides extremely strong electric fields within tabletopsized areas, can serve as a potential supplementary method. Focusing specifically on the (γ, p) generation of the vital medical isotopes 47Sc and 67Cu, we used both experimental results and PIC-GEANT4 simulations to demonstrate that laser-induced photonuclear reaction is a promising method for isotope production. We developed a model capable of calculating isotope yields under various laser conditions and acceleration mechanisms. The findings revealed that a 200 TW laser can sufficiently produce diagnostic amounts of 47Sc and 67Cu, while simultaneously providing high specific activity, which is significant in medical applications for improving treatment efficacy, enhancing image resolution, and reducing side effects.