HD患者的运动控制环路异常模式研究

ttention deficit / hyperactivity disorder (Attention Deficit / Hyperactivity Disorder, ADHD) patients with widespread impulsive, hyperactive and other typical symptoms, so motor control loop may be abnormal in patients with ADHD. Resting state fMRI outstanding performance network abnormalities in brain function study in patients with neuropsychiatric disorders. In this study, we based on resting state fMRI images of 252 samples (144 ADHD patients and 108 healthy controls), through independent component analysis (ICA) to extract the resting state motor control network for each sample, and then for ADHD patients and normal controls motion control network conducted a statistical comparison. Experimental results show that compared with normal subjects, patients with ADHD motor control loop synchronous activity (coactivation) was significantly stronger than normal controls (p <0.05). ADHD patients showed excessive activity, impulsive behavior control difficulties and other symptoms may be related to the abnormal patterns of the motor control loop. The results of this study will not only help advance our understanding of the pathogenesis of ADHD, and have reference to aid diagnosis of ADHD based on magnetic resonance imaging.