自组装微/纳材料的刺激响应性形貌演化及细胞毒性

Stimuli-responsive self-assembly triggered by external stimuli has attracted tremendous interest in recent years, which can modulate the shape and/or other macroscopic properties. Various stimuli (i.e. pH, enzyme and light) are utilized to control the self-assembly process and prepare smart materials. The applications of stimuli-responsive micro/nano-materials in areas such as drug delivery and bio-imaging have become a research focus. The morphology of self-assembled micro/nano-materials plays an important role in their properties and functions. So the research of stimuli-responsive morphology transformation of micro/nano-materials can promote the insights into controlled self-assembly and simulation of biological self-assembly. When performing functions in living cells, the micro/nano-materials usually change their physiochemical properties such as shape and volume, which may cause cytotoxicity and influence on cell functions. Therefore, it is essential to study the stimuli-triggered cytotoxicity of micro/nano-materials, and this can be instructive for the construction of stimuli-responsive theranostic materials. This review summarizes recent advances in stimuli-responsive morphology transformation and cytotoxicity of self-assembled micro/nano-materials. Future perspectives for the further design and applications are discussed too.