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全科团队下临终期肿瘤安宁疗护的系统评价与荟萃分析

Efficacy of Community-based Palliative Care for patients with Advanced Cancer:A Systematic Review and Meta-analysis

中文摘要英文摘要

背景:社区干预是临终期肿瘤安宁疗护重要组成部分,近5年来鲜有国内外文献研究其在临终期肿瘤患者健康管理中的作用。目的:评价全科团队下临终期肿瘤安宁疗护疗效。方法:采用 Cochrane系统评价方法,中文以“社区”、“医疗模式”、“临终期肿瘤”等为检索词,英文以“Community-Based”、“Model of Palliative Care”、“Advanced Cancer”、“Quality of Life”,检索Cochrane Library、PubMed、Web of Science(WOS)、万方、中国知网期刊(CNKI)、维普数据库,对符合纳入标准的随机对照试验进行质量评价并提取有效信息进行Meta分析。结果:共纳入研究12项英文RCT(涉及患者2640例),9项中文RCT(涉及患者1105例)。Meta分析结果显示:全科团队下的医疗模式中,早介入的安宁疗护(Early Palliative Care, EPC)较常规肿瘤治疗(Treatment as usual,TAU)可改善临终期肿瘤患者的生活质量和症状严重程度。相对地广人稀的国家或地区如采用多机构协作模式,体量小的高福利国家或人口密集的地区如适配医联体模式对生活质量相关结局的改善更为显著。EPC较TAU能否改善抑郁症状、总体生存率存在争议,而对于入院率、住院天数次数等经济学指标的作用有待进一步证实。结论:全科团队下临终期肿瘤的EPC可改善临终期肿瘤患者的生活质量和症状严重程度,但在改善抑郁、提高生存率、降低医疗成本方面的作用有待进一步证实。

Background: Community intervention is an important part of palliative care for advanced cancer. However, there is little literature to study its role in the health management of patients with advanced cancer in recent years. Objective: To evaluate the efficacy of palliative care for advanced cancer based on community resource. Methods: Cochrane system evaluation method was used to search Cochrane Library, PubMedWeb of ScienceChina Online Journals(COJ),CNKI and Cqvip databases with "Community-based", "Model of palliative care","Bilateral-referral", "Advanced Cancer" and "Quality of life" in both English and Chinese, The quality of randomized controlled trials meeting the inclusion criteria was evaluated, and the effective information was extracted for Meta-analysis. Results: A total of 12 RCTs were included in the study, involving 2640 patients. Meta-analysis showed that early palliative care (EPC) could improve the quality of life of patients with advanced cancer compared with conventional cancer treatment, reduce the degree of symptoms, but failed to improve depressive symptoms, and did not reduce their admission rate. Otherwise, its impact on the number of hospitalization days, the rate of emergency treatment and other related indicators of health economics needs to be further confirmed. Different models of palliative care should be adapted to national conditions and circumstances.Conclusion: EPC for advanced cancer based on community resource can improve the quality of life and symptom severity of patients with advanced cancer, while its role in improving depression, improving survival rate and reducing medical cost needs to be further confirmed.

洪景、郭晓冬、胡婧伊

10.12074/202210.00070V1

肿瘤学医学研究方法

社区全科医疗模式双向转诊临终期肿瘤Meta分析生活质量

ommunity-basedGeneral Medicine practiceModel of palliative careBilateral-referraldvanced CancerMeta AnalysisQuality of life

洪景,郭晓冬,胡婧伊.全科团队下临终期肿瘤安宁疗护的系统评价与荟萃分析[EB/OL].(2022-10-13)[2025-08-10].https://chinaxiv.org/abs/202210.00070.点此复制

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